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Ask HN: Getting started in biology with a software background

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Re: Ask HN: Getting started in biology with a software background

#61

I'm curious who all these sarcastic bio "experts" are that are suggesting getting a PhD or hiring one. I'm a former bio major and researcher/scientist that transitioned to software engineering years ago. I've published papers in bio and worked with many PhDs. Many of them were idiots. Being a PhD doesn't mean anything, it's the independent work that you put in yourself (in an academic lab or by yourself) that determi…

I think for non scientists looking to work in biotech, it is critical to also understand how the industry works and how value is created. That's the failure point for most biotech startups -- they dont have a useful application of their tech, or the useful application takes costs too much to develop compared to the value it creates A practical way to do this is to invest in biotech stocks. This will expose you to cli…

> "That's the failure point for most biotech startups -- they dont have a useful application of their tech."

This is precisely the failure of every academic ever. We can examine this through the Theil-lens where they're trying to create a narrative of uniqueness where their research applies + revolutionizes everything ( when it does not ).

But everyone knows this is not the case. This is the central plague of all academic research, that its the pursuit of novel understanding before useful application.

I would argue that this is more a defining characteristic of the current academic pyramid scheme than biotech startups.

Biotech startups dont go out for VC unless they HAVE a market.

Biotech phds go to the NIH regardless of whether theres a market.

Re: Ask HN: Getting started in biology with a software background

#62

I'm not a scientist but have worked in biotech in VC, started a venture backed therapeutics company, and worked with the life sci group of a FAANG. Having a PhD is not essential -- I know many successful VCs, founders and operators without PhDs -- but you absolutely need an appreciation of science. People like to hire PhDs because they have a fundamental knowledge of biology and or chemistry and they have deep experi…

I appreciate the plug to your blog -- subscribed! I really like your latest post about Genentech. I never knew how related they were to Apple.

Re: Ask HN: Getting started in biology with a software background

#63

I'm in my 5th year of a chemical biology PhD and I'm looking to potentially move into computer science/data science (been programming for 15 years) after I graduate. Maybe we can just switch? I work with CRISPR for my project. In all seriousness, you are going to need a PhD if you want to truly understand all of the background of the field. Human biology/biochemistry is just about the most complex thing humans have e…

Hire the PHD.

God knows they'll work for 3rd-world labor rates.

Re: Ask HN: Getting started in biology with a software background

#64
post #50

Earlier quoted context omitted.

you probably can, but it's hard to know what will be in demand without doing a lot of customer interviews with the people who would need your service.

Where is the best place to meet the right people? I talked to my friend (PhD) and she explained the process of conversion from Illumina file formats all the way to numpy , but I would love to know more.

boston is the best place to meet people in biotech. more specifically, it depends on the kind of data product you're trying to make. there are a plethora of networking events for biotech in the area, and a lot of the local nonprofit institutions will have valuable people for you to meet as well.

Re: Ask HN: Getting started in biology with a software background

#65

I'm in my 5th year of a chemical biology PhD and I'm looking to potentially move into computer science/data science (been programming for 15 years) after I graduate. Maybe we can just switch? I work with CRISPR for my project. In all seriousness, you are going to need a PhD if you want to truly understand all of the background of the field. Human biology/biochemistry is just about the most complex thing humans have e…

> you are going to need a PhD if you want to truly understand all of the background of the field Is that the need, though? Few SaaS CEOs truly understand all the background of computer science. They do understand the problem space, but they leave it to the experts in the organization to get into the details of applying computer science to the problem. Is biology different, where the level of expertise needs to be at…

This is the central argument for pursuing a phd.

But its rubbish.

Speed + onus behind learning > everything.

Also note the self-serving bias where Phd's swear:

"You need a phd"

Re: Ask HN: Getting started in biology with a software background

#66
post #14

Earlier quoted context omitted.

Can you explain your reasoning behind need a PhD ? It makes sense to me why you should learn a lot to understand a complex field, but I fail to see why you should also spend a few years researching a very narrow subfield... wouldn't it be better to be a generalist and be able to apply your knowledge widely, as opposed to only understanding a tiny sliver of the whole field?

You don’t need a PhD, but it helps. If you want to have a decent shot at getting funding from biotech VCs, the team overall needs experience in biotech AND startups, and the less experience the founder has in biotech the more the team will require to compensate for the deficiency. And vice versa for business experience, a freshly minted PhD is going to need team members with significant biotech BD experience. A PhD o…

> "You don’t need a PhD, but it helps."

> "A PhD is nice because because it demonstrates ..."

An employees willingness + investment to singularly do just one thing for the rest of their life.

It works as really good signaling for a CEO / hiring manager to assess someone as a really consistent employee.

Re: Ask HN: Getting started in biology with a software background

#67

my background is in biotech and i've worked at a small handful of biotech startups in a scientific capacity. here's my advice: unless you have friends who can set you up with the right VCs and ensure that they will be willing to overlook your lack of experience and IP, don't bother. you're not going to get up to speed working in the lab on your own in any short amount of time. learning the theoretical stuff that you…

Why are Phds so cheap to hire if their skills are so valueable?

Re: Ask HN: Getting started in biology with a software background

#69

I'm not a scientist but have worked in biotech in VC, started a venture backed therapeutics company, and worked with the life sci group of a FAANG. Having a PhD is not essential -- I know many successful VCs, founders and operators without PhDs -- but you absolutely need an appreciation of science. People like to hire PhDs because they have a fundamental knowledge of biology and or chemistry and they have deep experi…

I appreciate the plug to your blog -- subscribed! I really like your latest post about Genentech. I never knew how related they were to Apple.

Thanks! I didn't realize the connection until recently either. Bob Swanson is a very underrated founder
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