In the end, I decided against it. At the (2-day) job interview, people who worked there pointed out that the biggest benefit over Europe was the perceived freedom, the feeling that noone would bother them about their private business (this is probably no longer the case / general feeling today). I found the poverty in urban areas most shocking (loitering people, obvious racial inequality).
In the end it boils down to whether having your "dream job" (for me it was game programming) is worth both getting ripped out of your surroundings and coping with lower standards in many areas in the US over Europe (well, depends on whether you live in a poor EU country), as well as other issues like the harsher environment (floods, earthquakes). 50-60 hours was a given in the 90's, perhaps it is no longer the case now that Google/FB set the bar higher for job quality. For me it was better to stay, although nowdays I sometimes ponder moving to Switzerland, Norway or perhaps Australia (for different reasons, none involving career perspectives).