Ok, so this proved to be more difficult than I anticipated and it took me a while, but fortunately I really enjoyed the challenge!
It seems that the answer is definitely "yes", it can be done with WhyML.
There are a few minor caveats:
1. I had to change the function with the while loop to return an option instead of raising the Not_found exception, which makes the code a bit uglier. This is because I ran into the following bug in Why3 (it's already fixed in the master branch, but not in the most recent release): https://gitlab.inria.fr/why3/why3/issues/214
2. It turns out that the value of "high" is not statically known at compile time, because it depends on the size of the array. So I changed "high" to be a function of the array rather than a constant (I did the same to "low" for consistency).
3. Similarly and consequently, the predicate P(i) is not only a function of "i". It's also a function of the value being searched for ("x"), i.e. if P(i) is true or not depends on which value you're searching for. This also means that P() is also a function of the specific array being searched for (because some arrays may have "x" but others not).
4. You said that "we're pretending to know that there is a small value at arr[-1] and a large value at arr[arr.length]", but unless I misunderstood something, we can't actually pretend that, this must be written in the code somewhere, otherwise it won't work. For simplicity, I have chosen to implement those rules in the predicate itself. However, this is also enforced by the function with the while loop, i.e., it always makes sure that whatever predicate you have chosen, it has to implement those rules. I am sure that this could be changed, but I think it would complicate the proofs.
The result is that in module "GenericBinarySearch", like the name says, we have a neat generic binary search function which works with any predicate P (called "pred" in the code), any function "low", any function "high" and for any type.
And in module "ArrayBinarySearch" we have an instantiation of "GenericBinarySearch" which works for sorted arrays!
Also note that the axiom in the code is only an axiom in the generic module (it specifies what must be true of P()), but when the generic module is instantiated, Why3 verifies that the axiom is actually true for the specific instance of the predicate (so there is no cheating).
You can find the code in the link below. Enjoy!
https://clbin.com/Ov3NX