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Ask HN: How do you critically evaluate scientific papers?

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Re: Ask HN: How do you critically evaluate scientific papers?

#41
post #20

I think a lot of people outside of academia misunderstand the role of academic journals. To academicians, the journals are more like "interesting lines of research" rather than "settled results". Likewise, "peer review" typically just means that 3 academics read the article and thought it was interesting and worth publishing. It's important to recognize that a reviewer accepting an article for publication does not im…

Yes and no. They're "interesting lines of research" except when they're in your field, then they're foundations or anchor points for your work, past, present, and future. I'm not going to disagree that a lot gets lost in translation between academic article and the lay-person who hears a story on the nightly news, but I don't think gatekeeping academic research is the answer, but rather more emphasis on critical thin…

> I don't think gatekeeping academic research is the answer

Not sure what you mean by this? The journals are inherently gatekeeping academic research via peer review. But the suggestion isn't that the journals be locked away, merely that journals are not a great way for the public to interact with academia. Many academicians do write for the public and are eager to do so, but in different forms than journal articles.

Re: Ask HN: How do you critically evaluate scientific papers?

#42
I want to pass forward words given to me during my masters (by a prof Michel Bouvier if interested) that has stuck with me forever, on how to read a paper:

1. Read the abstract super carefully. Typically nothing in a paper that’s not in the abstract should be considered as absolutely confirmed by that paper. 2. If you’re new to the field, you can read the introduction. Ideally you shouldn’t need to. 3. Directly skip to the FIGURES. You should not read the results section! That is textual interpretation of the results from the authors’ perspective. If the paper is half decent you shouldn’t need to, everything the paper tries to tell should be fully substantiated and synthesiZable from just the figures and the legend. Especially biology. 4. Most definitely absolutely skip the discussion, it’s literally what the authors want this paper to be and should not affect your judgement.

The most interesting part is this is hard for a beginner or someone outside the field. But I think this is a good yardstick - if you can’t impute the results from just looking at the figures, the combination of you and the paper is not sufficient for you to fully evaluate that scientific finding to any degree of certainty.

Re: Ask HN: How do you critically evaluate scientific papers?

#43
Depends on the field a bit, but my general process involves using a few questions to signal one way or the other.

1. What are the actual claims made by the authors? That is, what do they claim to have found in the study? If you cannot find these, there is a good chance the paper is not particularly useful.

2. For each claim, what were the experiments that led to that decision? Do those logically make sense?

3. Are the data available, either raw or processed? Try reproducing one of their more critical figures. Pay close attention for any jumps in series (e.g. time suddenly goes backwards -> did they splice multiple runs?), dropped data points, or fitting ranges. If the data are not available, consider asking for them. If the code exists, read through it. Does the code do anything weird which was not mentioned in the paper?

4. How do they validate their methods? Do they perform the appropriate control experiments, randomization, blinding, etc? If the methods are so common that validation is understood to be performed (e.g. blanking a UV-Vis spectrum), look at their data to find artifacts that would arise due to improper validation (e.g. a UV-Vis spectrum that is negative).

5. Do they have a clear separation of train and test / exploration and validation phases of their project? If there is no clear attempt to validate the hypothesis for new samples, there is a good chance the idea does not transfer.

Re: Ask HN: How do you critically evaluate scientific papers?

#44
post #5

None of these. Assume any individual paper is wrong. If it's not your current area of research, you can afford to wait for the results to be reproduced (or disproven, or failed to replicate), and read a meta-study instead. Due to a minefield of mistakes like publication bias and multiple hypotheses, not to mention overt fraud, it seems more likely that an exciting result is wrong than that it's correct.

Given a paper, how do you find out if it was reproduced, disproven, or failed to replicate?

You can traverse citations to that paper, looking for anything which actually talks about those results.

There are some tools which do this. scite.ai has proven okay for quickly finding some of these citations, sometimes. Nothing beats manually digging in, though.

Re: Ask HN: How do you critically evaluate scientific papers?

#45
post #20

I think a lot of people outside of academia misunderstand the role of academic journals. To academicians, the journals are more like "interesting lines of research" rather than "settled results". Likewise, "peer review" typically just means that 3 academics read the article and thought it was interesting and worth publishing. It's important to recognize that a reviewer accepting an article for publication does not im…

I’ve long wanted some sort of platform for reading somewhat simplified, summarized research papers on topics of interested. Something a little simpler than an original paper, but more accurate and in-depth than what you might find in a popular news article. I haven’t found anything loke that yet, and I don’t know if it would be feasible to crowdsource summarized publications. AI summarization isn’t quite good enough…

I would recommend “news and views” from nature or review articles in general for a broad summary of a field.

Re: Ask HN: How do you critically evaluate scientific papers?

#46
If you need a better way to read arXiv papers, I've built Smort.io . You can read, edit, annotate, share and save papers natively in Smort rather than handling PDFs!

Here is a demo https://smort.io/demo/home

Just prepend smort.io/ before any arXiv URL to read. No login needed!

Re: Ask HN: How do you critically evaluate scientific papers?

#47
'Critical evaluation' in reality may not be possible if you're not already at least fairly familiar with the field, and the kind of techniques used in the research. If you were working in the field and were thinking about trying to replicate the work, or build on it, generally the procedure is something like:

1) Read the abstract, to see if it's something you're interested in and willing to spend some time one. Reading the introduction will often help here as well.

2) Read the materials and methods section and attempt to reconstruct in your head or on a piece of paper exactly what the structure of the research was. If you're not familiar at least a little with the field this may be a rather difficult exercise, particularly if they use techniques you've never heard of. However, without going through this, you can't really do any critical evaluation of the research. This can be the most difficult part; understanding the techniques (and their various pitfalls etc.) may require reading other papers cited in the bibliography.

3) Read the results, and in particular, focus on the figures, which should correlate with the materials and methods section fairly well. Here look for things like error bars, statistics, clarity, etc. Poorly written papers tend to obfuscate more than enlighten. There should be good correspondence between materials and methods and results.

4) Finally, read the discussion. Overblown claims that don't seem supported by the results are not that uncommon, so retain a healthy sense of skepticism. A paper that discusses uncertainties in the results in an upfront manner is typically more reliable.

Thorougly evaluating a paper in this manner is quite a bit of work, and can take hours of effort, even by someone with actual research experience in the field.

Usually, if it was a field that you are not that familiar with (say as an undergraduate student or a new graduate student), you'd start not with research reports, but with published reviews of relatively recent work, which will give you an idea of what's mostly settled and where the controversies are. If you were completely starting from scratch, a well-regarded textbook could be a better option as an introduction.

Re: Ask HN: How do you critically evaluate scientific papers?

#48

Earlier quoted context omitted.

That and don't just read the abstract or conclusion.

And how would I know if a given paper is of interest for me if I don't read the abstract?

Don't just read the abstract. I didn't say to not read the abstract.

The reason I say this is that there have been numerous cases where someone has tried to discredit one of my claims by citing a paper, and then I actually Sci-hub it and find out that the body of the study only weakly supports the conclusion, or that the study protocol contains a huge caveat not described in the abstract.

Re: Ask HN: How do you critically evaluate scientific papers?

#49

Earlier quoted context omitted.

And how would I know if a given paper is of interest for me if I don't read the abstract?

Don't just read the abstract. I didn't say to not read the abstract. The reason I say this is that there have been numerous cases where someone has tried to discredit one of my claims by citing a paper, and then I actually Sci-hub it and find out that the body of the study only weakly supports the conclusion, or that the study protocol contains a huge caveat not described in the abstract.

I now noticed that I read your comment in the opposite order: "just don't read the abstract". I am glad I asked you, though, because I see your point and I agree with you for I have seen this happening before.
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