Earlier quoted context omitted.
Hmm. I was kicking the wheels on cinnamon the other day - but because it's not on Wayland it won't do mixed resolution displays out of the box, so it's not really viable for me. A pity, as I dislike snaps and the generally dumbed down direction of recent Gnome, so it would otherwise have been a good fit for me. For now I'm (still) on Ubuntu though.
X11 has been able to do mixed resolution from the beginning. http://wok.oblomov.eu/tecnologia/mixed-dpi-x11/
Edit - To add a little context since that on reflection seems too dismissive...
I did try a whole bunch of things a while back, include several variations on xrandr stuff. I never did get to a place where all the following were true:
Both screens were operating at their maximum resolution
All app windows were appropriately sized (readable fonts, correctly scaled menu bars, etc.)
Neither screen was blurry due to scaling
I wouldn't swear it was impossible but with recent versions of Ubuntu under Wayland I could have all three without having to do anything at the command line.I love the command line. I just don't find messing around with config to make the basic system stuff work properly edifying.