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Ask HN: What interesting problems are you working on?

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Re: Ask HN: What interesting problems are you working on?

#371
I was burned out at my old job, got a new job that ays better and with better work/life balance, so now that I have some spare time, I decided to start something. Then I met Stoicism (Marc Aurelius & Co.) which made me re-think my drivers for starting a business.

So I took a few steps back, getting deeper and deeper into Stoicism, and brainstorming new Stoic-based business models in the e-commerce space, or Art, or both!

Re: Ask HN: What interesting problems are you working on?

#372
post #249

Decentralization and bidirectional real-time communications. I don't mean blockchain. I mean no servers with end-to-end encryption, no third parties of any kind.

How do endpoints find each other?

That is a different but very real problem.

Without consideration for mobile where IPs rapidly change currently it’s based upon IP swapping and I recently added a convention to auto-update addresses when a node makes a connection to other trusted nodes.

Later I envision an optional opt-in service that resolves node identity to IP address. Something like DNS but for hashes instead of domains.

Currently I am focused on updating a bunch of test automation and then I want to turn my attention to adding a command shell to the application GUI, which would solve for SSH into remote personal devices in your node list.

Re: Ask HN: What interesting problems are you working on?

#373

I recently looked up shape matching with OpenCV for a game I'm making. Basically, you draw black and white images by spawning meatballs, then the drawing is rendered to a image and checked against a reference using openCV. I found gesture algorithm online's but they always take into account individual strokes, and the drawing system is not using strokes. I also have requirements to match the *whole* image but not *ex…

Not quite sure what you're looking for but opencv's contour functions might help you here

https://docs.opencv.org/3.4/d8/d1c/tutorial_js_contours_more...

There's also a method of calculating the similarities of two areas called Union over Intersection, which is easy and quick to calculate.

Although it sounds like you got it figured out, so don't let me over complicate something that's already working.. :)

Would be interested in seeing the game!

Re: Ask HN: What interesting problems are you working on?

#374
post #6

A little while ago, a patent for high throughput DNA synthesis using silicon chips went off-patent, so I have been learning analog IC chip design to build an open source high-throughput DNA synthesis chip. If it works, and I sold them at cost, it would reduce the cost of oligo pool synthesis by ~100x and possibly gene synthesis by 10x. For about 8-9 years now my goal has been to build a cell from scratch for less tha…

I'd just like to echo (verbally "vote") my concern. Every great step forward comes with the potential for an order of magnitude steps backward, i.e. destruction. The amount of man hours to e.g. blow up a building is far fewer than the amount needed to build it.

Will the output of your product add a suicide timer to a cell?

Will the output of your product prevent the cells from procreating/multiplying?

Will the output of your product prevent pathogen creation?

Will the output of your product require a specific, unnatural energy source that can only be man made?

Professionals take great care in thinking about those problems, and sometimes still fail. (IIRC, a synthesized breed of mosquitos that were released in Brazil failed to die off and are now a part of the biosystem).

[0] https://www.dw.com/en/genetically-modified-mosquitoes-breed-...

Re: Ask HN: What interesting problems are you working on?

#375

Earlier quoted context omitted.

Vets have crazy high margins, and thus salaries, so from an outsider perspective perhaps the market is ready for some more competition.

those savings don't go to you, at least not the majority. It goes to the starbucks ceo that turns the industry into a sweat shop.

Ok, but that is a wider problem. At least vets have better salaries than most other employees in the same business-construct.

Perhaps they should start a union, like the rest of us?

Re: Ask HN: What interesting problems are you working on?

#376

I've been working on a programming language for UI designers. To put it simply, I think the trend towards no-code/low-code is misguided. The assumption behind these products is that code is slow, difficult, and expensive. I disagree - I think that "code" is merely a formalized written expression of what you want. It's actually the most efficient, easiest, and cheapest means to solving digital problems. I believe anyo…

I love the idea of this, but I just learned about xstate.js. It was a eureka moment for me. Why was UI design such a mess? It’s because the UI vocabulary came from publishing and graphic design, but UIs are not static and describing them in that way will always fall short. I’m convinced that any UI language needs to incorporate a visual state diagram editor to really make a dent in the space. UIs are not fixed object…

One of the premises behind the language is parametric rendering. So nothing described with Matry is static.

The difference, however, between Matry and something like xstate is that the actual state is intended to be left to developers, because I’m trying to create an interface that allows designers to just focus on what they need to focus on.

So take something like dark mode. A designer might allow for a Boolean parameter that determines whether a component render in dark or light mode.

But as to whether the browser supports it, or whether the user has that mode set in their system preferences - that’s the developers responsibility.

That doesn’t fully answer your question but it’s a complex topic so hopefully that gives you an idea as to where my thoughts are going.

Re: Ask HN: What interesting problems are you working on?

#377

I ended my career in June, and I am attempting to entirely reinvent my professional life at 36. It's interesting going through this sort of open ocean search having a little bit of savings and stability, but the stakes feel higher (emotionally) even though, rationally, I am in a better position to take on risk than when I was young and completely broke. The hardest part of it is actually deciding what do I want from…

Hey germinalphrase, I'm doing something similar after leaving my job earlier this year.

I took a bit of time off, then started exploring how people use their time on sabbatical to learn new skills, work on personal projects, raise kids, travel, etc.

After talking with a bunch of people about their experiences, the high-stakes feeling you observed is pretty common - I think people tend to underestimate the emotional aspects of taking a break from work.

My current transition plan is to spend a bit more time studying sabbaticals and turn that into something concrete (a book/guide and coaching) before doing some part-time consulting with my professional skills (marketing analytics) to cover my living expenses ala CoastFIRE.

I think there's a gap in part-time professional work - it's really hard to find long-term, part-time positions that take advantage of professional skills and offer benefits.

If you want to bounce ideas off someone who is also trying to thread the needle I'd love to chat more.

Re: Ask HN: What interesting problems are you working on?

#378
post #374
post #6

A little while ago, a patent for high throughput DNA synthesis using silicon chips went off-patent, so I have been learning analog IC chip design to build an open source high-throughput DNA synthesis chip. If it works, and I sold them at cost, it would reduce the cost of oligo pool synthesis by ~100x and possibly gene synthesis by 10x. For about 8-9 years now my goal has been to build a cell from scratch for less tha…

I'd just like to echo (verbally "vote") my concern. Every great step forward comes with the potential for an order of magnitude steps backward, i.e. destruction. The amount of man hours to e.g. blow up a building is far fewer than the amount needed to build it. Will the output of your product add a suicide timer to a cell? Will the output of your product prevent the cells from procreating/multiplying? Will the output…

> Will the output of your product prevent the cells from procreating/multiplying?

How would unicellular organisms procreate exactly?!

I am not being pedantic here but procreation usually entails sexual reproduction and I don't see how this is possible for these organisms.

Re: Ask HN: What interesting problems are you working on?

#379
post #28

Earlier quoted context omitted.

Sounds fascinating, what could possibly go wrong? “Your scientists were so preoccupied with whether or not they could, they didn't stop to think if they should.” —Dr. Ian Malcolm (Jurassic Park).

“Possibly” is the crux of that question, as it requires knowledge and expertise to answer in any kind of real way. It’s very easy to come up with answers to that question if you don’t know what is actually possible. Not very useful answers, though.

> “Possibly” is the crux of that question, as it requires knowledge and expertise to answer in any kind of real way.

That is untrue. If you mean by "...it requires knowledge and expertise to answer" domain knowledge.

It is possible to understand the implications of technology without mastering it.

The experts in the field have huge incentives to say it is safe.

If we are to make decisions about releasing novel self replicating organisms into the environment, we should not task the people who will profit (scientists) to decide if it is a good idea or not.

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