If you're coming with only %20 down in the Bay Area, you will turn cash poor, unless you're a millionaire. So think about that first, buying a house is the best mid-long term investment in life. But property tax here on a $1 million house is $10-12k per year. Home owner insurance is about $2-3k per year. So you're at about $12-15k extra per year (+$1000/month) just for the fact that you own a property. Now, the property itself will cost you about $4500/month at %3.8 APR for a $1 million house with %20 down.
Total of about $5500 net per month. Basically a bit below the average salary of an experienced software engineer in the bay area. And for $1 million, you don't get much here...