Ask a mainframe shop. The back-compat date for mainframes, even just-off-the-line System Z boxes, is 1964. --edit-- I also play Commodore 64 games in emulators, and they date from the 80s, but I suspect this is not the sort of answer you're looking for.
I took a look into it and the oldest macro I could find that I use semi regularly is SYS1.MACLIB(DCBD). A utility for working with data control blocks which dates back to 1977, putting it at 36 years old.
There are definitely older programs on the system, but I'm not sure how often they're used.