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Ask HN: Reading recommendations for understanding food allergies?

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Re: Ask HN: Reading recommendations for understanding food allergies?

#21
I have an unusual food allergy to poultry. I had the same question - seeking deeper understanding so I could better manage my life.

I searched online, had family in the medical research hunt for papers and finally made an appointment with a renowned allergist in DC - I flew there just for the appointment.

I left disappointed. My allergy is too unusual, there is no research available. What I need does not exist. For the common allergies - like kids and nuts - there are plenty.

The net/net from my experience is seek out an allergist, and be very specific in your requests.

Re: Ask HN: Reading recommendations for understanding food allergies?

#22

pre-note: the allergies are examples, as I'm not sure the specifics here. The money you'd spend on just going to a specialist will far outclass what you are going to find online. They are able to isolate exactly what is causing the allergy and intolerance. Personally, I don't think that food allergies are increasing so much as there is a wider understanding of allergies and intolerances (there is a difference). Condi…

But good luck finding a specialist highly conversant with MCAS if your allergies are not IgE reactions.

Re: Ask HN: Reading recommendations for understanding food allergies?

#23
My recommendation is that you read this regarding food allergies.

What I do is (1) avoid the medical community like the plague (except for dentists); (2) take other advice without immediate rejection, unless it is plainly wrong, but skeptically nontheless; (3) over a long time gather relevant information and always be on the lookout for it; (4) try some of this information in practice with personal experiments to see if and how it works and do not expect it to work forever if it works at first; (6) try to define what exactly you mean by "food allergy" preferably before attempting to fix it.

Generally what has helped me has been a balanced lifestyle with moderation in all aspects including diet, sleep, exercise, work, play and spirit, since they all interplay, but this balance may be highly individualized and can take some trial, error and instrospection to determine and may vary with time. In USA society work can typically be a big imbalance and has been so for me.

My experience is that much of what people commonly call food and other "allergies" is due to cumulative negative emotional responses or stress often coinciding with a lack of happiness in life. In such cases the cure is to find and be that hapiness.

Re: Ask HN: Reading recommendations for understanding food allergies?

#24
From my perspective as someone who suffers from IBS I understand why there is debate about seeing gastroenterologist & dietician vs a naturopath.

From what I have read, I think the reality is that gut based science including microbiome research is an emerging field with a lot of research in flux and it may be years before we fully understand everything. Because of this and just like deep learning you see a number of papers coming out almost everyday about diet, microbiome, brain-gut interaction, probiotics, prebiotics etc. Out of these a lot of the research needs to be backed up and there is just not enough yet to fully show a specific plan.

Unfortunately a number of gastroenterologists dont seem to keep up with research and I have even had one doctor tell me that everything is in my head. Things like these make you lose confidence in doctors and its understandable why some people turn to naturopaths even though a lot of it is quackery. I recommend working with a good gastroenterologist and a dietician to personalize your diet.

For IBS related personally I recommend following research coming out of Monash university.

I also recommend books Mind-Gut interaction by Emeran Mayer and The Good Gut by the Sonnenburgs

Re: Ask HN: Reading recommendations for understanding food allergies?

#25
post #11

Not a doctor but same experience and took a scientific approach which at the end was just about removing food and having a clean home. I wrote a short comment about this before [1] but will expand here: 1/ You need to know the kind of reaction they have. Go to the allergist. If they are gastrointestinal or if they are respiratory or of another kind. The first type can be solved after one year, the second is more dang…

This is true for IgE allergies, but many (sometimes life-threatening) mast cell reactions don't involve IgE and are very difficult to diagnose, since tryptase levels are very hard to measure properly, and the specific variant (alpha) of tryptase is relevant, and that pretty much requires a genetic study only available from one source right now. It is always good to find triggers - but these can be very numerous (ofte…

> and that pretty much requires a genetic study only available from one source right now.

What is the source?

I forgot to mention that both daughters had blood in the stools after eating allergens. This is commonly connected with cow's milk protein intolerance but can happen with other allergens.

Re: Ask HN: Reading recommendations for understanding food allergies?

#26
post #25

Earlier quoted context omitted.

This is true for IgE allergies, but many (sometimes life-threatening) mast cell reactions don't involve IgE and are very difficult to diagnose, since tryptase levels are very hard to measure properly, and the specific variant (alpha) of tryptase is relevant, and that pretty much requires a genetic study only available from one source right now. It is always good to find triggers - but these can be very numerous (ofte…

> and that pretty much requires a genetic study only available from one source right now. What is the source? I forgot to mention that both daughters had blood in the stools after eating allergens. This is commonly connected with cow's milk protein intolerance but can happen with other allergens.

https://www.genebygene.com/products/TPSAB1-Copy-Number---Cli...

This is the original study, the test may derive from its authors: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5397297/

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