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Ask HN: What startup/technology is on your 'to watch' list?

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Re: Ask HN: What startup/technology is on your 'to watch' list?

#191
post #31

zksnarks https://blog.ethereum.org/2016/12/05/zksnarks-in-a-nutshell/ Essentially let’s you verify computation is accurate without doing the computation yourself, and even treating the computation as a black box so you don’t know what is computed. Many applications in privacy, but also for outsourced computation.

One important weakness of zkSnarks is that it requires a trusted setup, for example [1]. A new alternative is called zk-STARK [2], which doesn't require the trusted setup, and is post-quantum secure. However, it significantly increases the size of the proof (around ~50KB). In general, hash-based post-quantum algorithms require bigger size and it would be interesting to watch the progress made in this regard. [1] http…

If I'm not mistaken, I believe they're found a way for a trustless setup a few months ago. Unfortunately I don't have any more info on hand, but I remember reading that in passing in regards to research performed by Ethereum developers.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#192
post #132

Earlier quoted context omitted.

Tesla covering 3/6... stock price is definitely still low

I would never trust any self driving car that didn't use LiDAR. It's an essential sensor for helping to fix issues like this: https://www.youtube.com/watch?v=1cSw4fXYqWI&feature=emb_logo And it's not contrived since we've seen situations of Telsa Autopilot behaving weirdly when it sees people on the side of billboards, trucks etc.

[deleted]

Re: Ask HN: What startup/technology is on your 'to watch' list?

#193
post #11

Rainway: https://rainway.com/ Google Stadia: https://stadia.google.com/ It's not even about gaming. Fuck gaming. It's about the underlying streaming technology. Imagine this same tech being used by a surgeon to perform surgery remotely. That's the type of use case I'm thinking about!

the reason these things work is because they use a datacenter in your city. Thats why low latency. You'd have to have doctor in the same locality, which is not what I think you are thinking.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#194
post #19

Web Assembly It's interesting in a bunch of ways, and I think it might end up having a wider impact than anyone has really realized yet. It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies, and so on. It looks like it's going to enable a wider variety of languages on the web…

> It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies,

Imagine if the crowd didn't fall for the HODL hypers and called these things cryptolotteries or something like that -- they are a betting game after all -- how ridiculous would it look to include them in every discussion like this.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#195

Earlier quoted context omitted.

+1, very excited about this. They're marketing it in the OLAP space right now, but at some point I'd like to try integrating it with a web framework I've been working on.[1][2] It'd be a more powerful version of firebase's real-time queries. Firebase's queries don't let you do joins; you basically can just filter over a single table at a time. So you have to listen to multiple queries and then join the results by han…

Thanks for the vote of confidence! One thing: We're not marketing it in the OLAP space. Our existing users very much are building new applications. Initially we went for the metaphor of "what if you could keep complex SQL queries (e.g. 6-way joins and complex aggregations, the kinds of queries that today are essentially impossible outside a data warehouse) incrementally updated in your application within milliseconds…

Ah, thanks for the correction. In any case I'm looking forward to trying it out eventually--got a number of other things ahead in the queue though.

My suggestion would be consider comparing it to firebase queries. Firebase devs are already familiar with how incrementally updated queries can simplify application development a lot. But, despite Firebase's best marketing attempts, the queries are very restrictive compared to sql or datalog.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#196
post #105

Earlier quoted context omitted.

Current methods can pretty easily identify the virus from just your spit (in fact, that's a protocol that is pretty widely used for different applications). The biggest problem is that normally you need to concentrate the virus in order to get detectable range for earlier days of infection. Seems like the range is approximately ~2 days earlier with concentrating vs spit only, which is actually significant. All diseas…

We're a nanopore sequencing shop. Couldn't agree with you more that nanopore generally is the future, not just for sequencing. Can't wait for ONT's solid state nanopore flow cells - you may get flowcells that go 2/3 times as long then. But then for most things .. the problem is the prep, not just because the whole portability thing goes for a toss. Yay, great the sequencer is the size of a USB drive, but the rest of…

The key is to do barcoding at the PCR amplification step. That way, you can get away with barcoding hundreds of samples in a single tube.

Really the prep screws it any other way. Is ONT coming out with solid state? Got a reference?

Re: Ask HN: What startup/technology is on your 'to watch' list?

#197
post #129

- Far UVC lights (200 to ~222nm) such as Ushio's Care222 tech. This light destroys pathogens quickly while not seeming to damage human skin or eyes. - FPGAs. I'm no computer engineer, but it seems like this tech is going to soon drastically increase our compute. - Augur, among other prediction platforms. Beliefs will pay rent. - Web Assembly, as noted elsewhere. One use case I haven't read yet here is distributed com…

> Far UVC lights (200 to ~222nm) OK, these are not safe wavelengths, and whatever you're reading is not right. This is absolutely ionizing radiation. The rate of formation of thymine dimers in this regime is similar to that around 260 nm. That is, it causes DNA damage. Please see Figure 8 below: https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1751-1097.... The logic of the claim that you can destroy a pathogen with…

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552051/

> We have previously shown that 207-nm ultraviolet (UV) light has similar antimicrobial properties as typical germicidal UV light (254 nm), but without inducing mammalian skin damage. The biophysical rationale is based on the limited penetration distance of 207-nm light in biological samples (e.g. stratum corneum) compared with that of 254-nm light. Here we extended our previous studies to 222-nm light and tested the hypothesis that there exists a narrow wavelength window in the far-UVC region, from around 200–222 nm, which is significantly harmful to bacteria, but without damaging cells in tissues.

> As predicted by biophysical considerations and in agreement with our previous findings, far-UVC light in the range of 200–222 nm kills bacteria efficiently regardless of their drug-resistant proficiency, but without the skin damaging effects associated with conventional germicidal UV exposure.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#198
post #194
post #19

Web Assembly It's interesting in a bunch of ways, and I think it might end up having a wider impact than anyone has really realized yet. It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies, and so on. It looks like it's going to enable a wider variety of languages on the web…

> It's an ISA that looks set to be adopted in a pretty wide range of applications, web browsers, sandboxed and cross platform applications, embedded (into other programs) scripting, cryptocurrencies, Imagine if the crowd didn't fall for the HODL hypers and called these things cryptolotteries or something like that -- they are a betting game after all -- how ridiculous would it look to include them in every discussion…

What are you adding to the discussion? This is a technical forum, the least you could do is comment on the use of Web Assembly in Ethereum or maybe anything of substance. There's a bunch of technically interesting topics to bring up but somehow I doubt you know anything about them.

Re: Ask HN: What startup/technology is on your 'to watch' list?

#199
post #94

Darklang: https://darklang.com/ I've tried out an early version of their product, and I really like where they're headed.

I’d love to try it if they didn’t tie the language to their hosting service. I understand the necessity of the coupling but until someone can start a competing hosting company with the same language, it’s not something I’m interested in.

Huh, Dark looks pretty similar to what I'm doing, albeit significantly more work since they went and developed a whole language and editor. If you're not averse to Clojure, give this a look: https://github.com/acgollapalli/dataworks
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