5x5 and "Starting Strength" are pretty fucking horrible suggestions for an older guy who has been sitting at his desk for 20 years. If you're a beginner, you WILL damage your joints starting with these programs. 5 sets of 5 reps with heavy weights is very nearly the worst thing you can do. Please do not follow this advice. I learned all of these lessons the hard way, but you don't have to.
* If you want to start strength training, start with 20 reps for at least a year.
* If you can't do 20 reps, the weight is too heavy.
* If your muscles are sore for more than two days, the weights are too heavy.
* If your soreness is anything other than very mildly uncomfortable, reduce the weight, not the reps.
* By very mild soreness, I mean very, very, VERY mild.
* If you have even the slightest joint pain, reduce the weight.
* If you hear popping and snapping of your tendons as you move through an exercise, reduce the weight.
* Never go to failure.
* Never train unless you've broken a mild sweat with your warm-up first. (10 min on a bike, etc...)
* Never train unless you allow time for cool-down afterward. Mild, post workout cardio significantly reduces muscle soreness in my experience. Shoot for 15 min. minimum cool-down.
* Very slowly start increasing weight each week or month. If you have no muscle or joint soreness, it's probably safe to increase a little.
* Be very patient. Body changes over 40 take a lot of time and rushing things just leads to injury now or later.
* On non-workout days, try to stay active. Get out of your chair and get some mild exercise at least once an hour. Keep your blood flowing. This reduces soreness and aids in faster recovery.
* Don't skip workouts
* If you skip workouts and you have been increasing the weight, reduce the weight to less than whatever you were lifting in your last workout.
Have you every heard an old person complain that their muscles are not big enough? Have you every heard an old person complain that their joints are terrible? I've seen plenty of old guys with relatively big muscles that have trouble walking much less doing anything else. Don't ruin your joints with lifting heavy weights too fast. Whatever pleasure you get from strength and big muscles while you are still relatively young is not worth the joint damage you will experience later. Joints are the key to mobility and are far more important than muscles.