I was having huge problems with eyesight strain. Just after an hour of computer use I would see blurry, shadows, double, light sensitivity, etc. I was even thinking about changing my profession. I tried many things like blue light filters, eye drops, improved refresh rates, max-hardware-brightness with reduced software-brightness, different light bulbs, eInk, orange glasses, red light therapy, larger monitor farther…
Over the next two years, I was able to better correlate these symptoms with sleep deprivation, as well. Lack of glasses exaggerates fatigue, but fatigue onset is much more aggressive when I don't sleep enough.