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Ask HN: What did you find in your DNA using 23andme?

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Re: Ask HN: What did you find in your DNA using 23andme?

#2
My ideal wake time is 8:04am, I have fast twitch muscle fiber, I have lower odds of experiencing Parkinson's, Alzheimer's, and prostate cancer, and I'm likely to sneeze when the sun is in my eyes.

Nothing in my health report changed my life, but I have reached out to distant relatives I would've otherwise never known about.

Re: Ask HN: What did you find in your DNA using 23andme?

#3

My ideal wake time is 8:04am, I have fast twitch muscle fiber, I have lower odds of experiencing Parkinson's, Alzheimer's, and prostate cancer, and I'm likely to sneeze when the sun is in my eyes. Nothing in my health report changed my life, but I have reached out to distant relatives I would've otherwise never known about.

How did you find your ideal wake time?

Re: Ask HN: What did you find in your DNA using 23andme?

#4

My ideal wake time is 8:04am, I have fast twitch muscle fiber, I have lower odds of experiencing Parkinson's, Alzheimer's, and prostate cancer, and I'm likely to sneeze when the sun is in my eyes. Nothing in my health report changed my life, but I have reached out to distant relatives I would've otherwise never known about.

How did you find your ideal wake time?

https://you.23andme.com/reports/trait.wakeup_time/ (visit when logged in)

Re: Ask HN: What did you find in your DNA using 23andme?

#5
I learned I have a little bit of Jewish and Arab ancestry, wouldn't really say that I was surprising though. I also found out I have something called Alpha-1, unfortunately there is not much I can do for this condition but it did provide me with a reason to lay back on the cigars and whiskey.

Re: Ask HN: What did you find in your DNA using 23andme?

#6
I have a mutation in the MTHFR gene, which causes my body to be much less efficient at converting folic acid to folate than most people. It is also the likely cause for why I have low B12 on blood tests. Solution: eat lots of leafy greens and take a folate (not folic acid) supplement.

23andme doesn't report directly on this variant, but it is in the raw results. You can run your 23andme file through promethease.com (for a small fee) to get a report on variants like these.

Re: Ask HN: What did you find in your DNA using 23andme?

#7
My spouse did it and the results provided by 23andMe were next to useless. It told her interesting facts like that she likely has no dimples (she has them), and other meaningless crap.

However, she downloaded the raw data and ran it through Promethease[0] and it did supply some useful info about potential drug interactions, which has been useful.

She supplied a fake name to them, used a gift card to pay for it online, and told them not to use her data for ancestry and to destroy her samples after processing. We've since learned here on HackerNews from people who claim to have worked there that they do not follow-through on their promises to do those things. I have no idea whether that's true or not, but it certainly sounds plausible and is infuriating.

[0] https://www.snpedia.com/index.php/Promethease

Re: Ask HN: What did you find in your DNA using 23andme?

#8
I generally find it interesting to know as much about myself as possible:

- Found out I'm the most neanderthal of anyone in my family who has been tested.

- that I have the "short" genes in spite of being quite tall compared to average and the tallest in my family in my generation, my siblings have the "tall" genes in spite of being closer to average or below average respectively.

- that I'm related to celebrity chef Mario Batali -- sort of cool before he turned out to be a rapist.

- that I have increased warfarin sensitivity... not relevant now but maybe someday.

Re: Ask HN: What did you find in your DNA using 23andme?

#9
I highly recommend uploading your 23andme data to Promethease, which dramatically increases the amount of research matched to your genome and provides a better interface:

https://promethease.com/

I discovered that I have one copy of the Delta 32 mutation. Two copies provides nearly complete immunity to AIDs, but being lucky enough to have just one copy means that it will take significantly longer to get AIDS should I ever get HIV. Knowing that I'm resistant to noroviruses also makes me more comfortable about traveling.

I discovered I have a 7x risk of going bald, which wasn't exciting.

Beyond this, results have been too contradictory to make use of. Genetics are interesting, but our behavior has a much greater impact on our lives.

Re: Ask HN: What did you find in your DNA using 23andme?

#10

I highly recommend uploading your 23andme data to Promethease, which dramatically increases the amount of research matched to your genome and provides a better interface: https://promethease.com/ I discovered that I have one copy of the Delta 32 mutation. Two copies provides nearly complete immunity to AIDs, but being lucky enough to have just one copy means that it will take significantly longer to get AIDS should I…

Promethease has a really bad and confusing interface in my opinion... 23andme is much better designed.
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