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Midlife Vascular Risk Burden and Dementia-Free Survival Years

neurology.org

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Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#71

Post by scottious »

msie wrote: post #55
scottious wrote: post #46

Earlier quoted context omitted.

For those who are inclined, I recommend running instead (even if you think you aren't a runner) My body has been completely transformed from 15 years of running. I'm 5'7" and 135 pounds at age 41. My face looks thin, I have a better body than most 20 year olds. I gave myself the best gift that I could possibly give myself. If they could distill 15 years of running (5x per week) and put it in pill form, I truly believ…

All it takes? Omg, why not do it every day if you’re going to do it 5 days a week? 3 days a week sounds more reasonable.

I actually do run every day. I've only missed about 4 days so far this year. Anyway, 3 days of running per week is certainly better than 0.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#72

Post by throwawalien »

lukan wrote: post #11
throwawalien wrote: post #4

Earlier quoted context omitted.

yep. eat healthy food as much as possible. walk. exercise. and SLEEP.

"eat healthy food as much as possible." I usually stop, if my body signals me I had enough. (might seem like pedantery, but I know some people do believe it literally, that it is healthy to just fill themself up with "healthy food", but it is not).

haha yeah I meant like choose to cook the chicken in your freezer with some veggies over going through the drive-thru

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#73

Post by scottious »

drop_star wrote: post #69
scottious wrote: post #46

Earlier quoted context omitted.

For those who are inclined, I recommend running instead (even if you think you aren't a runner) My body has been completely transformed from 15 years of running. I'm 5'7" and 135 pounds at age 41. My face looks thin, I have a better body than most 20 year olds. I gave myself the best gift that I could possibly give myself. If they could distill 15 years of running (5x per week) and put it in pill form, I truly believ…

> For those who are inclined I'd actually recommend an incline treadmill. Roughly 10% grade 3mph will give you the same caloric burn as a run but will be significantly easier to perform and save your knees from the wear and tear of running.

The whole "running destroys your knees" thing is a very persistent myth. Running can cause temporary knee injuries, especially in beginners. In the long run it actually strengthens your knees. There has been quite a lot of research on this but unfortunately, it's still in the cultural zeitgeist that running is bad for your knees

Of course, every person is different. Anecdotally, my knees and hips are so much stronger now than they were 15 years ago after running over 20k miles.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#74

Post by jonfromsf »

criddell wrote: post #20
Aurornis wrote: post #8

> Maintaining optimal midlife vascular health was associated with up to 12.6 additional dementia-free survival years, Stay on top of your cardiovascular health. Even moderate diet and lifestyle changes can have a significant impact on the last decade of your life. These things compound over decades.

Being human, I think more about the number of dementia years than number of dementia-free years. Could having good dietary, sleep, and exercise habits result in living longer with dementia? I've hard about cognitive reserve and how healthy lifestyle choices can build that. But I never read about ways to minimize the number of years you have to live with dementia. I wish I could sign an order that would grant me a dig…

This is indeed a problem. My mom had excellent cardiovascular health (she walked hours a day, ate a mostly vegetarian diet, etc). She got Alzheimers at 65 and is now 82. She's been completely gone as a person for the last decade, but her body hasn't died yet. It's tragic.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#75

Post by bufordtwain »

sublinear wrote: post #6

> Hypertension was defined as a systolic blood pressure of 140 mm Hg or higher, a diastolic blood pressure of 90 mm Hg or higher, or the utilization of blood pressure-lowering medications. Whoever defined this, thank you for having common sense! This stood out to me because there are so many lunatics defining it as 121/80 or even 121/70 with the backwards idea that the systolic is more important. Worse still is when…

Blood pressure varies significantly throughout the day and is often measured incorrectly at doctors offices. It's a good idea to get a home cuff BP machine and keep track of it yourself after reading up on how to use the machine. Otherwise you might get recommended medicine incorrectly, or you could get a false sense of security.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#76

Post by sublinear »

hombre_fatal wrote: post #60
sublinear wrote: post #34

Earlier quoted context omitted.

You're completely missing the point. There's a significant amount of people middle aged and younger with numbers something like 125/75. They may have that same blood pressure never change from about 20 years old until their 70s. Elsewhere they'd be borderline normal, but "in the west" (really just the USA) they're considered stage 1 hypertension and it's anyone's guess what wild nonsense the doctor will tell them onc…

Sure, at the end of the day you have to do your own research and consider whether any medical professional is under- or overreacting. It's why a second opinion makes sense. I have naturally higher blood pressure such that I'm usually 135/75 in the doctor's office. But I also run every day, I'm fit, and I have a dialed in diet. No doctor has given me flak for it. But I also see this thinking turn into empty contrarian…

I don't know much about keto/carnivore, but I think it might be worth picking apart the last thing you said.

There are far more people spreading misinformation about reducing dietary cholesterol and sodium because authoritative sounding organizations promoted it for so long.

The American Heart Association is paid by big pharma to talk out of both sides of their mouth. For decades they have strongly suggested that people consume less than 1500mg of sodium and minimize dietary cholesterol. In recent years they've been forced to admit that all that does is lead people to avoid better foods. Regardless, they still double down that the math makes sense on their old advice. They refuse to explain how.

The fact of the matter is dietary cholesterol has no impact on blood cholesterol, and most people need more than 1500mg of sodium to prevent low blood pressure and stay hydrated.

I have personally naively attempted to eat healthy by turning to salads, skipping dairy, and focusing on protein and carbs that contain lots of soluble fiber. I just ended up with severe constipation (too much fiber overall), vitamin deficiencies (animal products contain cholesterol), low blood pressure, and was getting dizzy and peeing all the time because I didn't think to get more sodium beyond seasoning.

What fixed it? Add the dairy back in (greek yogurt and cheeses), don't skip old school fortified breads/cereals (the OG ultraprocessed multivitamin), offal/organ meats, eggs, seafood, nuts, avocado, olive oil, etc.

It's one thing to say people have different bodies, but quite another to unwittingly support blatant lies.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#77

Post by reecardo »

KPGv2 wrote: post #36
jr3592 wrote: post #19

Earlier quoted context omitted.

Had an uncle who swore by this. He died at 57 of ALS. That obviously doesn't mean walking is bad, I just mean to point out that even those people who believe in it as a silver bullet, can be hit with something totally out of left field. Life is really quite brutish and short. You can do all the right things, and die early. All the wrong things, and live a long time. Take care of yourself for sure, but also find a bal…

The construction of GP and your post in sequence implies you think walking is not enjoyable. GP: Go walking. You: Instead, find a balance and enjoy life. Walking is very enjoyable. Try it! Bonus, you'll come up with some of your best ideas!

No walking sucks when you have bad knees, go biking instead, or rollerblading, or kayaking, or swimming, or whatever, just make a habit of being active every day.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#78

Post by ajx1001 »

n8henrie wrote: post #23
ajx1001 wrote: post #10

The work of Dr. Rick Johnson is perhaps relevant. He links the effects of fructose on the mitochondria, which then affects the neurons in the brain, over time. This hypothesis makes much more sense to me when you think to the associated diseases (diabetes, heart disease etc...) You can get a overview of his research on this podcast (approx 75min): https://www.youtube.com/watch?v=59Oje6n2JLU

In the context of TFA, what hypothesis makes much more sense to you than what alternative?

TFA? Not sure what you mean.

The hypothesis (I'm paraphrasing) is the fructose severely downgrades the mitochondria (this is well established).

The part that is really interesting to me is that patients with alzheimer's have huge amounts of fructose in their brains (that's covered the in the podcast).

So, lots of fructose, mitochondria impacted, thus neurons degraded. Makes sense to me.

As far as alternative hypothesis, there aren't any good ones that I'm aware of.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#79

Post by npras1 »

johsole wrote: post #7

The importance of walking can not be overstated. Walking for 30 mins every other day will dramatically improve your life if you are sedentary. If you can't do 30 minutes, start with 15.

Walking is great, and you should do it for reasons other than cardio/circulation health too (walk in nature, rest for eyes, ankle strength, socialising, touch-grass moment etc).

But if you're doing it primarily for health, there's one other thing I'd suggest.

High rep bodyweight squats and lunges.

If you build up to it very gradually there's no risk of hurting your knees. It's the best example of "motion is lotion". After a few months of daily squats, climbing stairs will feel effortless. I'm 40 and I can tell you you'll notice the difference.

A 100 squats at relaxed pace takes about 5 minutes for me. 10 mins for 150. 100 walking lunges in 10 mins. There's no hurry/competition. You can take your time to catch your breath. I've done 250 or so in 30 mins once every 2 or 3 weeks. But I feel that's not conducive to daily work. I get tired.

Once you get acquainted to this to the point where a 100 reps of squats/lunges don't make you sore the next day, or hurt the joints, then the heart rate you achieve from this will be similar to a relaxed zone 2 run.

And the health benefits are similar to walking. improved blood sugar and blood pressure.

My goal is to be able to do this for 20 to 30 mins twice or thrice a week. That might be some 300 to 400 squats.

I've been doing his way of training for a few years now, and I love it because this is what has be train consistently. not going to gym or tracks, or playing sports.

I like this, and recommend this over walking to anyone who can't seem to get the time to walk because it takes less time to get similar health benefit, doesn't need space/dressing-up/socialising/commute.

If you want info on this, kboges on youtube is the man. here are his amazing squat/legs related videos:

- https://www.youtube.com/watch?v=guG1LT7ejDU - he does 525 reps in one set. says it took him 20 mins

- https://www.youtube.com/watch?v=zWXToSCaq-Q - he does 100 constant tension squats in 2 mins

- https://www.youtube.com/watch?v=0euDDJu6GnQ - deep knee bends, aka hindu squats

- https://www.youtube.com/watch?v=TqNP_PiEalg - his take on squats busting your knees

ofc, not a doctor, dyor, listen for sharp pains etc and progress very slowly if you don't want to get hurt! you have your whole life to improve, so there's no hurry.

Re: Midlife Vascular Risk Burden and Dementia-Free Survival Years

#80

Post by avadodin »

MarkusQ wrote: post #59
citrin_ru wrote: post #54

Earlier quoted context omitted.

> healthy food isn't as tasty Mediterranean cuisine tasty and healthy. But it’s not as cheap as ultra-processed food.

The Mediterranean diet is tasty, but its supposed health benefits are mostly bunk; the whole "blue zone" longevity secret has far more to do with bad record keeping, pensions, and shoddy research than with diet. "Ultra-processed food" is a vibes-level concept that is likewise more scam than science. https://www.msn.com/en-us/health/mindandbody/the-real-secret... https://www.harvardmagazine.com/research/harvard-ultrap…

The alternative hypothesis is that their 100yo are healthy enough to scam the state out of their "120yo" parents' pension.

I've been in many of these miracle health countries and seen many 90yo walking around.

They all have some just–so story about a particularly awfully–tasting vegetable or drinking English gin every morning or whatever.

It most likely entirely genetic but we aren't ready to accept that we are what our genes are.

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