Viewing profile — vibrio

Wtf world do we live in that this sentence exists.

To add a somewhat cynical view, a significant part of the original motivation for the ranibizumab (Lucentis) development was due to pricing arbitrage across diseases. bevicizumab w…

I agree with you that AAV is clearly a useful tool but at times the low levels of self discipline and scientific rigor that the field has applied to dosing is disappointing at best…

I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into…

Maybe also an interesting case study in the inconsistent application of copyright law.

I think their point is not the ESG component, but firms with traditionally irrational valuations (à la GameStop) for which index inclusion exceptions have been made to facilitate s…

I can’t wait until Thanksgiving.

[dead]

Just in that it’s not gonna work.

…Better plan all day Better plan all week, better plan all month, better plan all year…. (Sorry, esoteric song lyric that applies.)

Interesting analogy.

This is interesting. As a naive user I’ve gotten the gut feeling of commoditization among the models. I assumed the data center capacity push is intended to be the differentiator b…

(not intending ot be snarky, but this isn't my area of knowledge in the least.) Didn't the AI organizations 'get it both ways' when they trained on vast collection of works under c…

You've succinctly identified and communicated a real problem. In your opinion, what is the best approach, if any, to attempt to address it?

Put this way, this seems reasonable. Beyond cell therapy, I don't thin the cost of drug is the motivation for not making it more freely available. 'Misuse' leading to potential lia…

So charging patients/insurance companies at cost to fund the clinical studies?

Not even cost plus? Not sure how that works, from the viewpoint of economic incentives.

Knowing whether drugs work isn’t trivial. Patients are typically very heterogeneous in their responses to drugs. For example, pembrolizumab (the most successful cancer drug ever) t…

Cane you provide a list of the “stupid” drug approvals?

lol. The battery life seems so short, I was starting to wonder whether this was the case...

Slightly different point but many bacteria in us right now also make lipopolysaccharide (LPS). If it were purified and injected iv, the LPS in me could probably kill me 1000 x over…

I agreee with the caution. I am not endocrinologist enough to guess what may happen and when. Because of the level of variably in all that is being experimented with, my guess is t…

Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest ma…

“Viruses” have a very broad feature set-beyond evoking Batman, it seems like a lot of details need to be hammered out here, even residually chlorinated water can be problematic in …

AIDS has been treatable for a few decades, with good progression getting it to developing world and some towards a cure. That said, some of this recent progress has been impeded du…