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toufka

HN member
Joined
Tue, Jan 24, 2012, 10:24 PM UTC
HN karma
3,496
Public activity
702 items

About toufka

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Recent public activity

  1. comment
    Comment #49250598

    I'm guessing - probably some textual variation on Benford's law? [1]. Trivial for compute, painful for a human. - "Ensure distribution of vowels is in >99th percentile of human wor…

  2. comment
    Comment #49184089

    The image size of this camera is unbelievably huge in its coverage. Most telescopes take pictures of objects - this one takes pictures of the entire sky. And will do so in a time-l…

  3. comment
    Comment #48645590

    Also the fact that the president’s daughter, son in law, and his brother have a significant amount of their net worth invested in OpenAI via Thrive.

  4. comment
    Comment #48527598

    The administration is not known for taking into account second order effects. The instantaneous instinct to strike an opponent when one can is not much more contemplated than that.…

  5. comment
    Comment #48454848

    How much did Apple (via Google (via xAI (via SpaceX))) just crush their product? Seems an awful lot like Apple will commoditize the models that power Siri, and just “sherlocked” a …

  6. comment
    Comment #48127873

    A large and rapidly growing number. The largest commercial classes of multi-domain therapeutic proteins include the crispr (and similar) that drive gene therapies, and the chimeric…

  7. comment
    Comment #48087549

    I mean, the most cutting edge of iPhones, iPads and MacBook Pros _today_ are quite capable of running in realtime today’s high-end local LLMs. If you project out that hardware just…

  8. comment
    Comment #47190261

    1) Another OpenAI cofounder (Brockman) gave Trump’s superPAC the largest ever individual donation of $25m. 2) Trump’s son in law (Kushner) has most of his net worth wrapped up in O…

  9. comment
  10. comment
    Comment #40965081

    A representative idea: if you are the one to kill a deer to eat, you get a little bit of each cut - rib, loin, filet, heart, etc. When was the last time most people ate a filet mig…

  11. comment
    Comment #40921106

    What about the heterogeneity of the original cells?

  12. comment
    Comment #40919078

    Yep - cells would die. ...UNTIL they accrue enough dna damage to accidentally either: - create a new way to generate thymidine - fall into a proliferation strategy that no longer n…

  13. comment
    Comment #40628774

    And that’s why replies are helpful in these kind of explanations. My over-edits became wrong, and then an hour later, unfixable. bglazer is correct. AAVs, unlike Lentiviruses, do N…

  14. comment
    Comment #40624796

    If the DNA is in the cell's nucleus, the DNA will be utilized to produce whatever gene is encoded in the DNA. But if the DNA is just floating around on its own it will not survive …

  15. comment
    Comment #39953436

    Timestamp in the videos: 21:03-4:33 => 7.5hrs

  16. comment
    Comment #39151029

    There’s one law of physics difference here: (with a few exceptions) helium, because it’s lighter than air, will never replenish on our planet. There is currently most of what there…

  17. comment
    Comment #38660324

    and youtube video of the 'reveal': https://www.youtube.com/watch?v=n--zawliqvA

  18. comment
    Comment #38236940

    Indianapolis was too fast and hot that one year, one of the (two) tire manufactures disqualified their tires (and teams). So not even half the field ran the race. The Indy 500 cour…

  19. comment
    Comment #37402089

    Snowden also brought the goods (actual docs) so that the existing cases and inquiries could proceed without getting the Glomar response - “cannot answer the question of whether you…

  20. comment
    Comment #36670617

    You (at least) have 3 systems that are optimized in concert in a (our) DNA/Protein world. DNA base set, Amino acid set, Translation layer between DNA/Proteins. Currently, we've got…

  21. comment
    Comment #36670565

    BUT, if you look at the codon table, precisely because it's base-4 and not base-3, many base flips are silent when coded. By using base-4, there's enough space to permit lossiness …

  22. comment
    Comment #35108679

    Which is why an enormous number of people will be fired, furloughed or reduced to minimum wage on Monday if this isn’t resolved.

  23. comment
    Comment #35099474

    And in this case, tech savy individuals are willing to send $XXM in 6 clicks, 3min after getting a slack message. That's a pretty quick kind of run relative to old-school 'stand in…

  24. comment
    Comment #33534159

    The quotes seem to be OCR’d with 500 being 5oo, and punctuation in weird spots too.

  25. comment
    Comment #33097557

    It seems “simple” from a chemistry perspective. But as pointed out, the special part is that this is simple chemistry, _that also works in standard biological conditions_ without h…