Viewing profile — stultissimus

PDX is a double edged sword. Human tumors are engrafted into mice with no immune system. Immune-cancer interface is incredibly important, yet completely lacking in these models. Co…

Reading life science textbooks and substacks is a great way to get started (see [1], [2]). Also, there is a major deficit of software engineering talent in biology research (probab…

This has actually been done for genetic circuits in E coli (bacteria) by Chris Voight's lab at MIT. Their platform is called Cello [1], and it enables interoperation between Verilo…

Synthetic biologist here. This is a good answer, but looking at man-made genetic programs can give us a simplified perspective. We've made significant progress engineering programs…

> If you don't mind me asking, how do you deal with this kind of culture, where a normal process is being purposefully obstructed with such behavior from the reviewer? A huge part …

In general we can conduct 'directed evolution' (selective breeding is an example). In this example, however, we're talking about improving the resistance of Halderia to the possibl…

Mutation rate ranges many orders of magnitude. See a figure here (linking a tweet (not mine) to avoid journal paywall, but underlying paper is linked in the tweet): https://twitter…

> 1. the parent raised questions in a neutral way. these questions seem essential for validating experimental design. why would peer reviewers present such questions in passive-agg…

Biophysicist here. Excellent questions – these are the kind of points peer reviewers would raise (though typically in far more esoteric and passive aggressive ways...). (1) could b…