Viewing profile — stenl

This seems to be the original: https://s3.amazonaws.com/b2icontent.irpass.cc/2660/rl168199.... (via CBS News: https://www.cbsnews.com/news/truth-api-trump-media/ ) So it seems to b…

My group published a cell atlas of the developing human brain in 2023, giving gene expression in single cells from postconception week 5 to 13. It’s on github: https://github.com/l…

He was not head of state when the crime was committed and he is not head of state now.

If, like me, you wanted to see the actual farthest distance photo, here it is: https://beyondrange.wordpress.com/

The average federal tax rate is 14%, and the USAID budget was about 0.8% of the federal budget, so you’ve been paying about a 0.1% tax to fund USAID.

A much more detailed and thoughtful (and peer reviewed) take on the same question from my colleague Jussi Taipale: https://www.embopress.org/doi/full/10.15252/embj.201696114

Cool! Has anything similar been attempted in tumor tissue, given the many claims of microbes in tumors? Especially tumors not in contact with the exterior.

And further down: ” Contributions J.J. and D.H. led the research. J.J., R.E., A. Pritzel, M.F., O.R., R.B., A. Potapenko, S.A.A.K., B.R.-P., J.A., M.P., T. Berghammer and O.V. deve…

These cells won’t divide because they will fail to replicate their DNA due to the lack of thymidine. The use case is cell therapies, where you give the patient cells grown in the l…

TERT activation is one of the most common alterations causing cancer. In fact, the whole point of the normally very low TERT expression in somatic cells is likely to be cancer prev…

Freezing and thawing organoids is not new, it’s fairly routine. The frozen piece of brain from an epilepsy patient doesn’t retain ”normal function”. There is no evidence in the pap…

”The Emperor of all Maladies” by Siddhartha Mukherjee is fantastic

Related: Dijkstra, ”Why numbering should start at zero” https://www.cs.utexas.edu/users/EWD/transcriptions/EWD08xx/E...

No that would be amazing. But we don’t have the technology to map all the connections in large mammalian brains. It was done in the fruitfly just this year: https://www.science.org…

None, that was done 100 years ago, e.g. by Ramon y Cajal (Nobel prize 1906). But microscopic detail does not give molecular detail. What these current studies add is data on gene e…

Papers are paywalled but most can be found on bioRxiv, e.g. https://www.biorxiv.org/content/10.1101/2022.10.12.511898v1

That’s not a terrible summary of the one paper, but there are 20 more papers. An overview by the Science editor: https://www.science.org/doi/full/10.1126/science.adl0913 The full c…

Yes, but at the same time most inbred strains have genetic disorders precisely because they are inbred. E.g. the most commonly used strain C57BL/6 develops age-related hearing loss…

Salmon and cod are both delicious.

Boston Globe did a long, thoughtful writeup of the whole affair a while ago, for those interested in more nuance. https://apps.bostonglobe.com/metro/investigations/spotlight/...

John PA Ioannidis, one of the authors of that paper (which is from 2018 btw) has published an average of 60 papers per year for the last decade, and more than 1100 in total ( https…

Some observations in support, by researchers at Yale: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4167193