Viewing profile — sdbrown

On a related-different axis, I've consistently seen on-prem GPUs running identical workloads ~35% faster than the same workloads on the same cloud hardware, regardless of intermedi…

Wasn't this part of the base thesis of "We Have Never Been Modern"?

Are you referring to Bruno Latour or the author of the post? If you're referring to Latour, I would strongly urge you to read "Laboratory Life", which is [as] clear and easy to rea…

I don't see dilution anywhere on that page, and increasing volume of administration at a lower concentration to achieve the same effective dose does not alter the dose itself. You …

That doesn't change the difference between effective and toxic doses, it changes the potential scale of off-by-one user error. If 20 milligrams is delivered in 1 tablet, then 3 tab…

Tadalafil (Cialis) is available as a generic in the United States. If you think "big pharma" is served by drugs going off-patent, you may want to re-evaluate your perspective. If y…

How, in your view, does dilution change the therapeutic index of a chemical? If a drug is effective at 20 milligrams, but at 60 milligrams has a steep rise in the incidence of hypo…

To me it sounds dialed-in even on immediate landing. Different strokes!

Apologies -- tetrazine reacts principally with trans-cyclooctenes. So azide/DBCO would be the orthogonal group. To the best of my knowledge, those two pairs do not cross-react.

Tetrazine/DBCO is also pretty popular IIRC.

Huh! https://biomedical-engineering-online.biomedcentral.com/arti...

I feel like fingerprint/iris/retinal scanners would be a reasonable stop-gap here if only there was some way to deploy them cheaply. Does anyone know if such add-ons exist that mig…

This is a fabulous convenience! The reach of this ready-to-go data will be much larger (in some directions) than the model and CASP results themselves.

See figure 3: https://onlinelibrary.wiley.com/doi/10.1002/advs.202100564 Doesn't the measurement of current in the presence of light mean photo-voltaic?

I appreciate your comment; medication saved me from tanking what has been a relatively successful career. However, they bring up a reasonable question, which is that of conflicts-o…

Literally LOL! My meds have been generic for so long that the most regular non-appointment-reminder phone calls I get are the pharmacy telling me that the manufacturer and appearan…

This was the biggest benefit for me.

It's been about 9 years and I'm still on the original dose of the first medication my psychiatrist prescribed. I'm really glad I managed my pride enough to make that first appointm…

I hadn't thought about that before! Very slick incentive structure there...like, build the tech to go to space and mine it and become enormously wealthy on Earth (ignoring the amou…

A k-D tree?

My partner is a physician, and this is _exactly_ how they manage disagreements about treatment plans, almost by instinct. It is amazing how well this works at clearing things up.

Or, can it (like humans?) adapt its responses to suit the style of the question? Like if you start asking it lots of antagonizing questions, will it become more or less antagonisti…

OK, slow down. What FDA actually said was "do not use ivermectin intended for animals on humans": https://www.fda.gov/animal-veterinary/product-safety-informa... Physicians can and…

I think this appeared on HN a few days ago: https://www.computerworld.com/article/2527153/opinion-the-un...

> People ITT blaming the OP don't understand this attack always works on a long enough timescale. I'm a little dismayed by the great number of comments I had to read before someone…