Viewing profile — rorytbyrne

I’m working on “Supabase for science”: 1-click deploy of scientific databases with validation, transformation, MCP, export-for-ML, and provenance built in. https://amacrin.com

I thought the HN community might have some ideas for this. Unconventional org charts, beyond PI + postdocs + PhD students? New tech to enable fully-remote research collaboration? N…

This is more on the ed-tech side right? I'm thinking more tooling to help a synthetic biologist design a protein, or a DARPA PM integrate the research activities of the labs they f…

I used to be a regular backend developer, then I started a biology PhD. It seems like lots of people do computational work, but the landscape of devtools is pretty sparse. This is …

Open Science Archive: open infrastructure for scientific databases, so that every field gets its own Protein Data Bank in 1-click. Code: https://github.com/opensciencearchive/serve…

Of course it's relevant to how it's seen today. French culture nurtured the author, a French publisher published it, and France didn't ban it while other countries did. This is all…

Ulysses was first published in Paris during the 20 years that Joyce lived there. >I thought only the US ranks it high Joyce never even set foot in the United States... You could sa…

Why is "singing along" a relevant metric? In Dublin's best music venues, nobody is singing along because it's brand new material from brand new artists. If you're singing along to …

Not sure what point you’re trying to make here in relation to startups.

A domain-agnostic, open source scientific database. “Protein Data Bank-in-a-box” https://opensciencearchive.org

A domain-agnostic, open source scientific database. “Protein Data Bank-in-a-Box” https://opensciencearchive.org

Not which parts of this are sarcastic or not, but it was probably running for a few weeks. High variance on that estimate though. I was running 5+ Claude Code instances and a simil…

I spotted Ghostty using 20GB+ memory a few days ago on MacOS (according to Activity Monitor). I went through all my tmux sessions, killed everything, it was still 20GB+ so I re-sta…

Relatively speaking, no. Strength training (as opposed to hypertrophy) calls for fewer reps, around 5 per set. Many people advise spending about a year doing more sets of fewer (~5…

> heavy weights with few reps (common body builder wisdom) It is strength training (not body builder) wisdom to use heavy weights with few reps. Hypertrophy (i.e. body builder) pro…

> Who else do you suggest and why are they better? The arbiters are just our colleagues, at the end of the day. The journal is just the organisational mechanism, one of many possib…

You pay them, they give your work a stamp of prestige that is mostly unrelated to the quality of your work.

> At that point why even have a journal Great question. > the journal system isn't perfect but its the only real check we have left. I wish I could agree but Nature et al continual…

Haha yes I jumped off in a very different direction. The points you raised are very much valid in the short-term. But longer term, I think journals charging authors for some kind o…

Yes exactly. Right now they are arbiters of quality but they shouldn't be, and the move towards Open Access is changing their role.

Indeed, they are irrelevant. Right now they maintain an administrative monopoly over the peer review process, that makes them de-facto arbiters even if it's peers doing the work. J…

I disagree. We haven't chosen quantity over quality, we have decided that journals should not be the arbiters of quality. I think these new incentives are exactly what we want: 1. …

https://opensciencearchive.org I’ve started building a domain-agnostic scientific data archive, inspired by the Protein Data Bank. It handles the deposition, validation, curation, …

I made a HN-like discussion forum for (meta)science. https://talk.amacrin.com/ Most (meta)science discussion is either fragmented on Twitter/Bsky, or a bit too formal. I thought a …