Viewing profile — reasonattlm

It is hard to cover everything related to longevity, given that there is a vast diversity of approaches, and a lot of work presently taking place. https://www.agingbiotech.info sho…

The 16S rRNA sequencing you are referring to is now quite cheap and efficient. [1] Viome is one of many companies offering this as a service. Viome isn't so good at giving you the …

It is interesting that they achieved any positive results with prebiotics. The animal study evidence suggests that these are weak interventions compared to fecal microbiota transpl…

We should treat this study and the discussion of the relevance of the results as being highly speculative. Firstly, near all genetic variants that have been found to correlate with…

An entire article pondering regional differences in COVID-19 mortality and severity without saying anything about differing demographics of (a) aging and its comorbidities and (b) …

For a fairly inclusive list of longevity industry companies: https://agingbiotech.info/companies

If you can get into an incubator lab space that isn't in a major market like SF or Boston, where the rents are insane, one can expect to set up a reasonable wet lab for most uses g…

Several research groups and companies are working on in vivo applications of cellular reprogramming. Since its discovery, reprogramming has been used to produce induced pluripotent…

This interesting open access paper recently published reports on the effects of hyperbaric oxygen treatment on telomere length and cellular senescence in immune cells taken from bl…

Some of the more noteworthy lessons I have learned to date as a result of running a longevity industry biotech startup, most of which likely apply to any biotech initiative, were i…

We don't need to end biological aging, just control it. Let aging run, producing molecular damage in tissues, and periodically repair and reverse that damage such that people don't…

Dasatinib + quercetin has been shown in a clinical trial to remove senescent cells in humans in much the same way it does in mice [1]. High dose fisetin (i.e. take a whole bottle o…

Still as relevant 15 years later, as we still live in a world in which aging can be addressed via the construction of rejuvenation therapies, but most people are simply disinterest…

No, no, no. This is just an argument for putting more effort into a failed strategy. The reason why we haven't made much progress towards extending healthy human life isn't because…

My company, Repair Biotechnologies, is working on regrowth of the atrophied thymus via FOXN1 upregulation. We're at the preclinical stage of getting the vector and formulation into…

One of those hidden powers is the destruction of the aging brain. Senescence of glial cells appears to be quite important in the progression of neurodegeneration, as both a source …

Any bio* field can lead to working on treating aging; at undergraduate level you have tremendous flexibility as to which direction you take. For now build connections. Go to the co…

A prediction: the generic, low-cost drug dasatinib, a senolytic that selectively destroys senescent cells and can pass the blood-brain barrier, will be the best Alzheimer's treatme…

I can't say as I like his take on the longevity industry. It is the take that will produce few meaningful advances, the "looking under the lamp because that's where the light is" w…

And yet the risk increase for dementia for people with periodontitis is not large at 6% in a recent sizable study. https://www.healthinaging.org/blog/periodontitis-may-raise-t...

Cancer research largely proceeds in the wrong direction, towards ever more personalization to mechanisms specific to one tiny fraction of cancer types, or tiny fraction of tumors i…

From the SENS point of view [1] a number of the Hallmarks are downstream consequences of the causes of aging; e.g. epigenetic alterations are a reaction to molecular damage. Attemp…

There are a bunch of other things that can't be fixed by delivering youthful stem cell populations into tissues, such as the presence of garbage molecules in long-lived somatic cel…

Testing per batch is needed when ordering direct from any manufacturer. In my experience there isn't any real difference in quality and order fulfillment between Chinese and non-Ch…