Viewing profile — philipn

Hi HN! There's been lots of note-taking / personal knowledge tools developed in the past few years. But there's a big difference between working with people you already know and co…

Me and my cofounder Chris have been quietly working on Encycla for a while now. Previously, I started LocalWiki[1] and DavisWiki[2]. What I couldn't stop thinking about was: is Wik…

Aaron Swartz actually built the original version of the Open Library site.

Yes, this is one reason why an approach using a form of soluble ACE2 is so promising; mutations that would normally cause e.g. monoclonal antibodies to stop working (as detailed wi…

The spike protein downregulates ACE2[1], which may make an otherwise benign respiratory infection severe[2]. 1. SARS1 spike protein itself, without any virus, causes ACE2 downregul…

It was not blinded. It was open-label and the outcomes were subjective (ICU admission). The doctors involved with the trial knew who got what and may have biased their actions base…

I think the table in that paper is just confusing. The parenthesized numbers are for portion of the total number of people, rather than the portion of that category. For instance, …

Please see my twitter account for lots on this. I'm in contact with a bunch of top researchers on this topic (renin-angiotensin system; ACE2/Ang 1-7/Mas axis; ARB usage for viral d…

List of repurposed drugs (not comprehensive) https://www.nature.com/articles/d41587-020-00003-1 Review of small molecule therapies (not comprehensive): https://blogs.sciencemag.org…

It is related, but it's pretty complicated. For some information on this and the potential relationship, see my twitter account: https://twitter.com/__philipn__

Edit: contact made, thank you! If anyone is reading this with connections to the Gates Foundation: Please contact Dr. Robert Kruse at John Hopkins. https://twitter.com/RobertLKruse…

Are registries allowed to charge different prices for different domain names? E.g. can they ask google.com for $1B to renew and mygrandmascookiecompany.com for $20 to renew?

One reason is constitutionality. The "One man, one vote" principal likely has to be upheld for a voting system used in the US to be ruled as constitutional. https://www.fairvote.or…

Ranked Choice Voting is sometimes called Instant Runoff Voting when used in a single-winner election. But it can be used in multi-winner elections. If it's used for a multi-winner …

I loved this passage! -- "..There was zero overlap between the provers and the bulldogs. I was expecting at least some overlap: somebody who mocked me but also provided a valid sol…