Viewing profile — pgcudahy

This is frustrating that it's marketed as FDA approved but people won't recognize that it is regulated as a medical device, which have to only show safety, rather than as a drug, w…

OMG, I went down the rabbit hole on this paper and it is bonkers. Their methodology is amateur hour. It's just an uncontrolled non-validated survey sent out by an activist group. W…

Not at normal doses. The therapeutic window is narrow, but they're used in millions of animals and we're not seeing an epidemic of seizures. https://www.merckvetmanual.com/toxicolo…

They target gamma-aminobutyric acid chloride channels (GABACl) that aren't present in mammals. There is a relatively narrow therapeutic index in animals, but generally felt to be s…

"I have not witnessed one machinist harmed by lead in 40 years." Do you know what you're looking for? Lead poising can be subtle but eventually devastating. This is like the asbest…

Has anyone tried the new anker or ecoflow lithium portable power stations as a UPS?

To get full approval they could combine this with animal efficacy studies like they did for the smallpox treatment tecoviromat, since you can’t give smallpox to trial participants …

I've got it running from a Pi3 with no issues serving to multiple roku clients simultaneously. I'm also really happy with how the roku client has gone from just working to well pol…

I would think of Henry Ford and the assembly line just prior to this period as the birth of modern manufacturing. Moving from artisans doing most or all of the work on an item to i…

There seems to be no analysis of whether these are neutralizing antibodies. The idea of using serology for immunity certificates or "golden tickets" is never going to go well. Even…

I think the last elections argue against that https://www.nytimes.com/2020/01/11/world/asia/taiwan-electio...

With only 58% sensitivity and 2 false positives for every true positive, this is going to be like the automated drug interaction checks that we all click through because they are t…

These articles are posted monthly and I love them. Great in-depth histories.

In this article and others I've read, people complain about the tidyverse's lack of performance, but I think that places too much emphasis on speed of execution versus speed of dev…

This article is based on the work of Richard Weller who is trying to monetize them at Relaxsol[relaxsol.com]. I didn't find any disclosure of this in the article. The mainstream vi…

This series of longform articles is incredible. The first batch are on the history of the switch and probably add up to a shortish book in length. There's a nice focus on how at se…

Looks like it's at stage two in the science hype cycle. http://www.phdcomics.com/comics.php?n=1174 I'll pay attention when a randomized control study shows that supplementing vitam…

For biomedical research supported by the US NIH they require it to be posted to PubMed central ( http://www.ncbi.nlm.nih.gov/pmc/ ) within 6 months of publication. Since so many bi…

It won't be catastrophic but it could affect them. Most pacemakers have a mode that if you put a magnet on them they revert to pacing at 60 beats per minute (VVI mode) like a metro…

"Its well established that no vaccine has an effect that lasts longer than seven years" Wrong. Every vaccine has a different level of immunigenicity that effects how long it is pro…

Why did Blackstone agree to go through this shady guy rather than just make the deal themselves? What does he bring to the deal?

The link is not to Damien's AnkiMobile which is the legit Anki for the iphone ( https://itunes.apple.com/us/app/ankimobile-flashcards/id3734... ) but to some other Anki I've never …

These calculators aren't just pulled from thin air, they use studies of various populations over time to derive a mathematical model that predicts the cardiovascular risk of a pati…

This is pure quackery. The cholesterol -> heart disease framework was developed by the Framingham studies ( http://en.wikipedia.org/wiki/Framingham_Heart_Study ) that showed a stro…