Viewing profile — pfisherman

Nice! Thank you for doing this. I am not surprised PCA holds up. It comes with some pretty strong theoretical guarantees. The problem with it has always been scalability. The O(n^3…

There are other reasons. One is for career development of your researchers. Another is to be good citizens, in good standing, in the community of scientific researchers. Another is…

I think land value tax is misguided. Issue is what happens to retirees on a fixed income when value of their property increases? Are they forced from their home to lower priced are…

My understanding is that an ideally priced IPO should not move much from the opening price in the near term. If it pops it means they left money on the table. If it drops, then I a…

You could drop the verb clause? This would make the headline accurate while keeping it punchy. > why Americans switch to soy And > why developers switch to codeberg But the cynic i…

Same experience with Fable. Utterly useless for anything bio related. Author of the post here wrote Salmon, which is a widely used bioinformatic tool in molecular biology. And the …

One quick piece of semantic and linguistic housekeeping for the commenters… Heritable != Molecular / Genetic Mechanism There is a conflation of these terms in popular discourse tha…

In some ways domain experience can be a hindrance, with ingrained pathways and practices shaped by constraints that no longer apply. My personal opinion is that you probably want a…

I don’t know about this. After some time sitting with it, I think that mid level and senior ICs - especially those slow to adapt - are going to be at risk of getting replaced by en…

The comment above is on to something. I find CarPlay to much more valuable and much more of a lock in to the iPhone than Siri. I do not think I could ever go back to using the info…

No you would not expect all efforts to target AB to work. You can have the right target and the wrong molecule. Look at GLP1s as an example. Multiple pharma companies tried GLP1 re…

I don’t quite follow the reasoning behind this being “unbiased”. Studies must be designed to answer specific research question. What is the question being asked by the study in que…

Nice work! Here is an article you may find helpful if you have not already come across it.[0]. You may also want to consider benchmarking against some non ML methods.[1] 0. https:/…

This is going to catch some heat, but what if the most important professional “developer skill” to learn or improve is how to effectively use coding agents? I saw something similar…

I think Peter Thiel is smart, but exhibiting one of smart people’s most common modes of failure, overestimating one’s ability while not maintaining a healthy sense of skepticism ab…

Yeah, you are not wrong. The topic is a bit like troll bait for me. Probably because I have a first hand view of how the current strain of anti intellectualism and resulting policy…

Yes, and they are currently cleaning our clock when it comes to global competition in science and technology.

We live in a globalized economy. Rapid transport of people, goods, and information necessitates it. The high paying STEM jobs will go to wherever there is an abundance of talent, a…

I associate this phrase with losers and people trying to sabotage the US. You know who is not wringing their hands about “elite overproduction”? China, who are pumping out tons of …

This is very easy to explain. Anthropic outlines some limitations in their terms of service. Palantir accepted those terms. The DoD did not. OpenAI claims their terms of service fo…

Would this actually return memories and context? How could you know if parts or all of it were hallucinated?

I can see how being able to bring your chats with you would be appealing. But the truth is that context rot is real, context management is everything, and more often than not stati…

Why not use Claude Code from the cli and follow along in your IDE? I did not quite believe when people were telling me or understand what I was missing until I tried it, but after …

Looks like the statistical geneticists have jumped the shark with this one. This big problem here is that their endpoint (chills) is poorly defined, reported by subjects (and thus …

FDA regulates the marketing of drugs and medical devices. This is a case of Hims and Hers (and other compounding pharmacies) marketing drugs without having been granted approval. T…