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panabee

HN member
Joined
Mon, Jul 04, 2011, 9:00 AM UTC
HN karma
4,353
Public activity
1,028 items

About panabee

Founder, Hotpot.ai and HotpotBio (Hotpot.ai/bio)

X.com/panabee

Please message for free Hotpot credits. HN is an invaluable source of knowledge. I would be honored to give back.

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Papers:

Hotpot-JOMI: Joint Outcome Model Interrogation for Reasoning Consistency

Patient.md: Framework to Organize Medical Data for AI Assistants

M.I.J.O.: Framework for Evaluating Applicability and Limitations of Biomedical Datasets with AI Assistants

Infection-Associated ME/CFS: Phenotypic Overlap, Craniofacial-to-Intracranial Sampling, and the J.O.A.N.-M.I.K.E. Frameworks

Reevaluating the Association Between Epstein-Barr Virus (EBV) and Breast Cancer in the United States

Recent public activity

  1. comment
    Comment #49238409

    The overall dataset was very large (8,972,221 deaths), but only 1,348 ambulance drivers were included, and just 10 had Alzheimer’s disease as the underlying cause of death. Such a …

  2. comment
    Comment #48016203

    How to notify you once v0 is ready -- just comment here?

  3. comment
    Comment #48016197

    How to notify you once v0 is ready -- just comment here?

  4. comment
    Comment #48004417

    Will aim to ground the framework -- Cancer Mini-101 for Engineers -- in personal use cases. I hope it will be helpful for you.

  5. comment
    Comment #48004395

    Great question. The bar for proof in biomedicine is naturally high. I only shared facts because so much is unknown. If you can find a lab exploring the question, maybe you can supp…

  6. comment
    Comment #48004375

    I will aim to put together a Cancer 101 for engineers, not sure how to share. Maybe I'll post here or will post to our biomedical GitHub so it can evolve over time?

  7. comment
    Comment #48003316

    For people questioning why to involve GPT and AI assistants: GPT and AI assistants cannot be fully trusted, but they can personalize learning. The chief challenge for the framework…

  8. comment
  9. comment
    Comment #48000546

    On second thought, I will publish something regardless of interest. It will be an "Cancer for Engineers" framework, delivered via free, open-source Custom GPTs and Claude Skills. (…

  10. comment
    Comment #47999670

    Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostim…

  11. comment
    Comment #47906580

    If you're a wealthy person lacking a neurobiology background, how do you decide which research efforts are the most promising? Which labs do you back? Generally, you rely on expert…

  12. comment
    Comment #47906440

    TLDR: gatekeepers stifled exploration and innovation. When a topic only has a limited number of experts, those experts become gatekeepers. Those gatekeepers directly or indirectly …

  13. comment
    Comment #47834497

    VCs are soccer stars, but founders play basketball. It’s easy to dunk on VCs, but the herd effect is rational after considering the typical VC’s background, the intense competition…

  14. comment
    Comment #45391432

    The association between pathogens and cancer is under-appreciated, mostly due to limitations in detection methods. For instance, it is not uncommon for cancer studies to design ass…

  15. comment
    Comment #45349553

    A more accurate title: "Are Cornell Students Meritocratic and Efficiency-Seeking? Evidence from 271 MBA students and 67 Undergraduate Business Students." This topic is important an…

  16. comment
    Comment #44661729

    Thanks. This is helpful. Looking forward to more of your thoughts. Some nuance: What happens when the methods are outdated/biased? We highlight a potential case in breast cancer in…

  17. comment
    Comment #44659912

    Valid critique, but one addressing a problem above the ML layer at the human layer. :) That said, your comment has an implication: in which fields can we trust data if incentives a…

  18. comment
    Comment #44659460

    If you agree that ML starts with philosophy, not statistics, this is but one example highlighting how biomedicine helps model development, LLMs included. Every fact is born an opin…

  19. comment
    Comment #44657381

    100% agreed. I also advise you not to read many cancer papers, particularly ones investigating viruses and cancer. You would be horrified. (To clarify: this is not the fault of sci…

  20. comment
    Comment #44657337

    To elaborate, errors go beyond data and reach into model design. Two simple examples: 1. Nucleotides are a form of tokenization and encode bias. They're not as raw as people assume…

  21. comment
    Comment #44657056

    This is long overdue for biomedicine. Even Google DeepMind's relabeled MedQA dataset, created for MedGemini in 2024, has flaws. Many healthcare datasets/benchmarks contain dirty da…

  22. comment
    Comment #44652872

    The author is a respected voice in tech and a good proxy of investor mindset, but the LLM claims are wrong. They are not only unsupported by recent research trends and general patt…

  23. comment
    Comment #44539041

    More like alarming anecdote. :) Google did a wonderful job relabeling MedQA, a core benchmark, but even they missed some (e.g., question 448 in the test set remains wrong according…

  24. comment
    Comment #44526043

    Thanks, but no one truly understands biomedicine, let alone biomedical ML. Feynman's quote -- "A scientist is never certain" -- is apt for biomedical ML. Context: imagine the human…

  25. comment
    Comment #44516197

    Agreed. There is deep potential for ML in healthcare. We need more contributors advancing research in this space. One opportunity as people look around: many priors merit reconside…