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orintorynchus

HN member
Joined
Tue, Jan 11, 2022, 4:10 PM UTC
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118
Public activity
12 items

About orintorynchus

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Recent public activity

  1. comment
    Comment #29896816

    Not exactly "finding out", but rather estimating. It's all about prioritizing testing through detecting suspiciously "good" and unexpected outliers popping up.

  2. comment
    Comment #29896775

    That's the key bit here. Supervised learning is not applicable here and any sort of fitting to known labels is doomed to fail. The system is not calibrated, tuned or parameterized.…

  3. comment
    Comment #29895120

    The idea is to introduce a bit of sanity into the current world, to calm down overreactions to every new, scary looking variant. And on the flip side - to identify the truly scary …

  4. comment
    Comment #29895086

    We are actively looking for motivated colleagues. Feel free to look at the page above or drop us an email at hello[at]instadeep.com. We are also happy to make new friends and work …

  5. comment
    Comment #29895024

    The method, in its current incarnation, is detecting dangerous variants and not foreseeing them. We can use the same approach to forecast plausible developments, but there are so m…

  6. comment
    Comment #29894611

    I am sure we will, in due time. If you have any particular hopes or wishes, we will try to accommodate as much as we can.

  7. comment
    Comment #29894517

    This is something that amazes me. Any time a true High Risk Variant appears, it is clear as day in the system. This was the case with Lambda, Mu (which we predicted to have a limit…

  8. comment
    Comment #29894395

    The system is constantly learning, so it "retunes" itself. We can infer epitopes from structure, but we found that data derived from known complexes is sufficient for our purpose. …

  9. comment
    Comment #29894267

    What we hope for is rather informing the public policy. Now, any time a scary looking variant is sequenced, there is some public commotion, uncertainty about the future repercussio…

  10. comment
    Comment #29894208

    Well, there is a lot of overlapping nomenclature. Here by variant we understand any sample, which is not identical sequence-wise to sequences seen before. Most of the observed muta…

  11. comment
    Comment #29893421

    It is not random. InstaDeep has designed, developed, built, benchmarked the method. BioNTech performed experimental validation, provided expert insight into the problem domain. Hen…

  12. comment
    Comment #29893397

    I am the second author of the paper. We have been putting our head on the line for the last half a year. We detected Lambda, Mu (with a caveat, that we did not consider it competit…