Viewing profile — notlob

[deleted, this was a total overshare]

Yeah, exactly. The linked article quotes parts of the suit that specifically say "nicotine salts" which I think is suggestive that this may be a big part of the case.

> JUUL is like any other nicotine alternative (e.g. gum) Not exactly so, a distinguishing feature of Juul is that the nicotine provided is formulated as a salt rather than as a fre…

What parts of this would you expect to be of interest for startups outside of digital, specifically biotech?

I see where you're coming from now. ABX (antibiotics) are a bit unique. New ABX are sparingly profitable because they are usually incremental developments instead of new classes of…

Public funds are used up to proof of concept and sometimes early tox/CMC (often through a CRO), but the bulk of the funding for trials comes from industry.

UPenn and Novartis brought Kymriah to market and Kite brought Yescarta to market. Universities can be great for discovery and sponsored research, but they are not leading the work …

This is an inaccurate portrayal of the pharmaceutical industry. Take CAR-T as one obvious counterexample.

Post-AIA, US utility patents (including APIs, biologics, methods of manufacture/use, etc.) are 20 years with possible adjustments to term length.

I’m not in IT tech, last job search a couple years ago took about a year and I’m starting another that’ll likely take as long. It’s just fantastic to me that multiple people could …

There could be a good blog post in that? Planning to do right by your employees, even when times are hard. (Also, I can't imagine what it'd be like for jobs to be easy to find!)

What happened with the people you had to let go? Did you prioritize rehiring them once your ship was righted or help them find new positions?

> If they don't, you have a job you otherwise wouldn't have had. No, you have a job for as long as you're able to keep your lie secret. Once the lie comes out, even if it's X years…

> It also depends of your tolerance of rednecks, prudes, puritans, and ignorant people (which exist everywhere in the world, but have particularly large concentrations there). FYI,…

> > > They timed production to maximize federal tax credits for US consumers. This is what is confusing me: if the credits are timed to domestic sales (so international sales don’t…

Can you quote the text here? For the life of me I can’t find the section you’re referencing. I’ve heard the “timing production to match tax credit” thing before and it doesn’t make…

Can you clarify, did Tesla announce this, or are you announcing this?

I wasn’t intending to advance an argument, merely present that as a biotech entrepreneur in the process of forming a new company I for one like many of the changes in this proposal…

One biotech person's perspective is that these are changes in the right direction. Things were certainly not perfect in the pre-AIA era, but post-AIA and recent court decisions hav…

> The reality is that HSR isn't cost-effective if the trip takes more than about 5 hours. Can you expand on that? It's not obvious to me.