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I spent the entire time reading it pondering the same thing. 1. The article presents that calling out to a tool like python is "expensive" because of the overhead of forking a proc…

Having worked on software that runs manufacturing plants your comment echos the idea that too many engineers have that they are "better" than manufacturing and lessons don't apply …

Depends on the microplastics, but many act as endocrine disruptors that "mimic" estrogen, tricking the body into over-activating ERa and upregulates the PEMT gene and the higher ac…

The non-DHA omega-3 EPA are good at preventing perivascular fibrosis and thus a better glymphatic system for the removal of beta-amyloid proteins. EPA also helps produce melatonin …

It depends on the person and their genetics. The further you get from the ERa the more complicated this gets and simply stating "Do X" wouldn't apply to everyone even if there are …

ERa activation promotes PGE2 resulting in decreased 15-PGDH. So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling …

I am not saying that if there was a pill on the market today that would increase plaque-clearing there wouldn't still be dementia, simply that they would probably then die from pne…

For this particular situation on D3 I personally (who is not your doctor) would go with vitamin D3-loaded nanoemulsion. The reason is that Vit D influences how tryptophan is conver…

The title is a bit link-bait. It should really be "Disrupting circadian rhythms of plaque-clearing brain cells is associated with Alzheimer's" > He found that too much of YKL-40, w…

Neanderthals had the FOXP2 gene, which is associated with speech and language.

And then this ties to estrogen, HRT is known to reduce the risk of dementia/AD ( https://pmc.ncbi.nlm.nih.gov/articles/PMC10480684/ ). PEMT (phosphatidylethanolamine N-methyltransf…

Tying this to APOE, specifically e4 which has an increased requirement for choline and when choline levels are low there can be a metabolic push that leads to elevated PHGDH activi…

Think questions where there is a ton of existing medical research, but no clear answer yet. There are a dozen alzheimer's questions you could for example ask which would require it…

I have a several complex genetic problems that I give to LLMs to see how well they do. They have to reason though it to solve it. Last september it started getting close and in Nov…

Sure, add a way to contact you to your account and I can send you over the current understanding.

The author also asks "If you were stranded on an island (or small hostile planetoid), what books would you want to have with you?" which I also can't answer. I would fall into the …

3 of the 4 dna samples show signs of nonclassic CAH. This limited their reproduction abilities as 50% of babies would have CAH and die at birth until they integrated with proto-hum…

If you mean ring type I don't remember which one worked best, sorry. As for my favorite EM field there is a nearby street with buried powers lines and transformer boxes at ground l…

I have had one of these for years and the right size makes all the difference. Some fun things include the ability to feel where the metal studs are in building walls, where the el…