Viewing profile — marchenko

I wonder if the researchers considered directly inoculating the colorectal area. Is it necessary for this to pass through the upper gut?

This seems like a pretty grass roots effort to me: mothers horrified that nude pictures of their 12yo daughters are being created with generative AI. These young girls (not yet wom…

Imputation is a fairly common technique that would be familiar to most molecular or computational geneticists, especially those used to working with poor samples. There are softwar…

The Substack is called “mostly Python”. I assumed the author is a programming educator or enthusiast of some sort.

The claim that the real value in art is in the idea rather than the execution seems to be as true as the claim that the real value in a startup is in the idea. Artists are constant…

A game whose popularity & longevity has become a cliché, Skyrim, is usually played in 1st person. Myst & Doom were both known for their ability to engage players in a flow state in…

Joel Spolsky used the dilemma of being ambushed on a minefield (to make a different and almost orthogonal point) in a way that illustrates how norms that are not individually usefu…

Right now we're in a transitional phase where DNA data is integrated with traditional police work, where there may be a priori reasons to suspect someone before invoking DNA data t…

Forgive my ignorance, but why do game servers ban Linux players in pvp games? Fear of some sort of modding only available on Linux?

I think the removal of agency and oversight from the public that is often coupled with "solutionism" - not lack of faith in technology - is a primary reason solutionism has met pub…

Women have tended to be over-represented in "support" rather than "line" positions within firms. Maybe it's more historically accurate to say that they are more likely to be tasked…

If this were true, and significant, wouldn't we expect to see more successful women in the startup scene? Women appear to be disproportionately willing to do low-status/non public-…

The Titanic is actually notable for being an exception to the rule of every man for himself, largely attributed to the action's of the Titanic's captain: https://www.independent.co…

I can see what he's getting at, at least if he's focusing on the SSC subreddits and comments. It's easier to be a brave truth-teller when it's not your ox being gored, and I think …

What convinced me to give Obsidian a twirl is that there's essentially no danger of sunk costs: I already store my notes as markdown files in a local folder synced via cloud servic…

I've been using Obsidian for about a week, and it may be the first time I've ever felt compelled to comment in an app's user forum. I even installed Discord so that I could subscri…

I think the poster has a good point. It's not just the one submariner study he's referencing that's relevant, it's the decades of experience navies of various nations have operatin…

'Late-stage' slavery, if it has a meaningful referent at all, refers to chattel slavery in the United States, which is commonly regarded as one of the worst forms of slavery ever d…

These kinds of professions are often referred to as "tournaments", a term I think captures their essence nicely. ( https://en.wikipedia.org/wiki/Tournament_theory )

Iceland has reduced the incidence of Down's syndrome by screening and terminating Down's pregnancies, not by medically resolving the underlying chromosomal nondisjunction. The role…

In fairness, it's not a crazy question - mushrooms contain a lot of undigestable and fermentable carbs (raffinose, chitin) that can affect ...passage...in some people, and cause fl…

It's not as formidable as it seems, once you question the premise that perfect enforcement of the laws is a desirable goal. Where, for instance, would the pressure to overturn anti…

The other side of this coin is the Preference Cascade, a concept from economics [0] wherein people formerly in a Spiral of Silence discover that their supposedly unpopular opinions…