Viewing profile — klmr

It’s a POSIX thing, and it has nothing to do with the file extension. The OP is right: file extensions are optional (and, as shown here, often actively misleading), but if they’re …

Oh, I totally agree that ‘renv’ probably solves 95% of problems. But those pesky 5%… I think that most problems are ultimately caused by the fact that R packages cannot really decl…

> But in all honesty for the pharmaceutical industry it’s mostly momentum that keeps R on top I can’t agree with this: especially in PK/PD, R is only just now taking over from the …

> I can’t remember the last time a library incompatibility led to a show stopper. Oh, it’s very common unless you basically only use much better (and ‘rig’ and PPM also help in sma…

> That's not a lot Indeed, that wouldn’t be a lot: the framing in the article is grossly misleading. The actual number of protesters this weekend was hundreds of thousands, and pla…

I’m not saying this doesn’t happen but I can’t remember ever having been asked to install a root certificate when joining an airport wifi. And I am confident that this has never ha…

> why are there not mass protests about this? Because we hadn’t heard about this case before. — At all. If the vague information in this article is actually corroborated there’ll b…

The entire point of TLS (let alone E2EE!) is to make something like this particular scenario safe.

Why? Because all typical, existing applications written for POSIX systems use the POSIX API (usually indirectly) to interact with the filesystem and perform IO. Being able to use t…

> … at Google, which i suspect is one of the companies you are referring to. Just to clarify: no, I was referring to companies which are using products from the company behind cuno…

> this is not a recipe for stability of your binaries I see the point in theory, but it works incredibly well in practice. The specific technology has been used in production by ma…

> but what has this to do with storage systems? The article is about POSIX compliance (or lack thereof) of storage systems. And the article does not imply that “POSIX … sucks”. On …

It’s pretty clear that the article is only comparing object storage with POSIX in the context of filesystems, not with all of POSIX.

If you save the offset (and you are , if you use a borrowed string) you can retrieve the original source code by re-reading the input file on the fly. This is expensive (due to IO,…

It’s also completely untrue. In reality the high cost is not because of greed but because of high manufacturing cost and the necessity for long hospital follow-up. Novartis is also…

> I recall when the pipe operator was first being proposed the argument for it was that it'd enable workflows that felt more like Excel. Where are you getting that from? To start w…

Yes, it switches to a different audio codec, that’s unavoidable due to bandwidth limitations. However, macOS insists on using a worse codec than necessary (SCO instead of SBC) and,…

Next week on HN: “curl: A command line tool and library for transferring data with URL syntax”. Anyway, the submission led to several very interesting technical comments so I don’t…

I’m a huge fan of the Sony high-end line, and am currently using the WH-1000XM4 myself. They’re excellent, but they do share quite a few of the annoyances listed in the OP article …

It’s a weird quote anyway since there is commercial, proprietary software for DNA sequence analysis. Just a few examples of companies in this space are Sentieon, Edico (acquired by…

I dunno, I don’t think it’s that obvious: the physical movement in an LCD is across tiny masses and distances (at molecular scale); the network signal has to cross a distance that’…

> it wanted to blast crap into /usr Homebrew only ever writes into `/usr/local`, which was unused by macOS until very recently (though unfortunately a few third-party tools also us…

> A modification in the frame of mind of genetic understanding is performed on a viral cell. Let me be frank: this sentence is nonsense technobabble. > A segment of viral genome wh…

> It is a simple fact that there are two major definitions on the Wikipedia entry for gene therapy: I read this as a single definition rather than two distinct ones but, regardless…

Title: “Manufacturing gene and RNA therapies” “A challenge for both gene and RNA therapies is getting the nucleic acid molecules into a cell. […]”