Viewing profile — klevertree

Wrote about this in the context of repurposing, which is a pet interest of mine: https://trevorklee.substack.com/p/another-entry-for-the-repu...

We're still prototyping and testing, but you'll probably have to eat it twice a day to get complete coverage. It needs to be in the gut at the same time as the plasticizer to have …

Not a bad idea for your health, but it won't trap plasticizers. We're modifying the beta glucan to have many tiny, "sticky" pores to trap the chemicals in the gut, so they go out w…

Reports like this on the dangers of DEHP is exactly why I started work on NeutraOat ( https://neutraoat.com/ ), a modified oat fiber supplement designed to trap plasticizers in you…

Yes, what do you think the pk trials and liver experiments would involve if not people who have a variety of phenotypes?

Author here. Thanks! I'm pretty sure most of the negative effects of SSRIs were discovered in phase 2 trials, though. Pk trials aren't usually powered to find adverse effects in su…

Author here. As someone who works in pharma, organ on a chip models are not even close to being relevant to providing accurate PK curves for oral absorption. The state of the art i…

Author here. That's not what I said. Please don't be a jerk on the Internet.

Cyclosporine and tacrolimus, if you look at the range in any of their pk trials you'll easily see 10 fold variability.

Author here. Enzyme polymorphisms are tricky and would require a whole different blog post. Some drugs they matter a lot for, some drugs they do not. I actually have not found any …

Do you have any connections there, by any chance? Always looking to talk to more vets.

The corporate attorney agreed not to require me to pay any of their invoices until I closed a seed round, while the patent attorney let me pay their invoices a full year after I re…

I'm sorry to hear about your calico. Stomatitis is really a terrible disease.

Unfortunately, the reality of trying to cure animals is that sometimes you accidentally hurt animals. That's also the reality of trying to cure humans. This is the exact same issue…

Trying to cure a disease that gives cats such bad mouth sores that they sometimes can't even drink water isn't exactly "pushing crap". We're trying to make it to profitability so w…