Viewing profile — jinder

Not just that. In mice, SSRIs stop having any anti-depressant effects if the vagus nerve is severed: https://www.nature.com/articles/s41598-019-50807-8 So they also seem to be effe…

While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t t…

Or perhaps there are significant links demonstrated in murine models of the multi-directional relationship of the gut-brain-immune axis, and that traditional models of disease are …

Where is the best-in-class evidence that CBT is effective at treating long covid and chronic fatigue syndrome?

Some people really do have mast cell issues, but everyone and their dog thinks they have MCAS these days and it's questionable in my opinion. Often a diagnosis will be based on whe…

Famotidine an old school H2 antihistamine used for acid reflux (pre PPIs), was found to have an additional mechanism of action via activation of the vagus nerve to inhibit pro-infl…

What bust are you referring to? As far as I can tell there's still considerable development going on all around London.

How do Christian contemplative traditions predate Buddhism if Buddhism arose in the 5th century BCE?

How have you determined that the excess deaths are due to "covid restrictions" and not for example, long term sequelae of covid itself or other factors?

I think the independent status of the City of London is grossly exaggerated and not really comparable with the Channel Islands.

And what makes you think that?

Er no - the loss of a mother is extremely traumatic to a child. It can lead to long term mental health issues and physical health issues.

To get to the point of re-joining will take a long time with plenty of time for governments and minds in Europe to change. Ultimately the EU is stronger with the UK as a member, an…

I've used SSP and let's just say I think it's nothing short of revolutionary. It seems to be completely changing how my brain works and how quickly it gets activated (in the sense …

Try to be born vaginally rather than c-section (might be too late for that!), avoid antibiotics unless you absolutely need them, polyphenol-rich whole food diet with diverse fruits…

My guess: Environmental toxins, antibiotic use and poor diet leading to loss of microbiome diversity/dysbiosis and consequential disruption to the body’s homeostatic processes.

GB is not more neutral - it excludes Northern Ireland, which is a part of the UK.

Yes - totally the opposite. In fact, I think the issue with Angular is that they've not finished the work to make Angular RX-everywhere (for example, reactive components need to be…

You're correct - it appears to work via the gut-brain axis, see my comment above.

To add to my comment, this explains why SSRIs take some time to work - it's the signalling through the vagus nerve that takes time to impact the brain. Other compounds such as curc…

SSRIs appear to work through the vagus nerve in a similar way to psychobiotics. Their direct effects on neurotransmitters are probably an unwanted side-effect: Oral selective serot…

No I don’t think it’s permanent - mine seems to be slowly and progressively improving. You almost have to retrain your autonomic nervous system on a step by step basis.

It's super super common for people to recover from covid, be okay for a few weeks or even months and then lapse into long covid. In fact, it's relapse-remitting for many people. If…

The vast majority of apps you see on the App Store, including most games can be web apps. So I'm not sure what your point is? Apple has deliberately under-invested in implementing …

Correct - after years of deliberately hobbling Safari so you couldn't build quality app experiences, they suddenly start releasing lots of useful improvement just as regulators are…