Viewing profile — hirenj

Yes, that is exactly what I meant! Here’s an experiment to try: Frances Arnold got a nobel prize for work related to directed evolution. However, we know evolution is limited by th…

I think there was a Twitter/Bluesky thread on the results from adding all the predicted folds from metagenomics too, and not ending up with many new clusters. If this continues to …

This approach is pretty much like the TED approach from a few years back. As far as I remember there wasn’t a ridiculous amount of fold diversity there either. It turns out evoluti…

This looks very cool. Does the window picker for multi-window apps work with the pinning? So if I have a safari windows I want to have associated with a profile, and the option-tab…

Even better, don’t ban it, but require companies to do age verification (above a certain age?) before displaying advertising. You get two wins in one: make the child market less at…

Can you say what field that is? I hear this sometimes, but my feed there is significantly low signal to noise, and I have had to pollute my “connections” to the point where I accep…

It is a huge worry for me that unless we decouple the publishing “system” from the career pathways (i.e., rewards), we are going to lose access to both the careers (to robot-weildi…

For prosterity, the original report on the pilot program with the checklist including introducing names of participants (doi 10.1056/NEJMsa0810119). Possibly popularised by Atul Ga…

That is really insightful regarding the ritual improving outcomes through better communication - something I see reflected in many meetings I turn up to now which involve an introd…

This is great - now I can get the authentic conference experience of a disengaged speaker reading out the slides in a monotone, without all the hassle of international travel and s…

I was ruminating about how Atproto would be great for re-thinking the peer review system for scientific journals. Imagine a world where a preprint is “published” onto the social we…

Arc institute probably.

It is a real shame that peer review reports were only first published relatively recently. These would have provided valuable training information as to what peer review performs. …

Not my subject area, but at least one other group looked at ABCA1, and judging from this abstract, it has been linked via GWAS already, and furthermore concludes it doesn’t play a …

I guess that whatever recognises the enhancers must be conserved ish in mice for us to be able to drop this region into the mouse genome. That might be interesting alone apart from…

My innate immune system is here for chewing gum and binding viral glycans, and I’m all out of specific lectins. Looks like this works by apparently binding complex N-glycans on the…

This is pretty interesting, also that they get it down to the amount of mannan in the fungal cell walls being somehow related to the β cell amounts. There's probably a nice project…

Ancient medicine solves that problem https://news.ycombinator.com/item?id=43196488

I think what you mean is the MUC1-20 (ish, numbering is a bit sloppy but hopefully we can clean it up in near future) genes encode for mucins, that are synthesised on a ribosome, t…

Mucins aren't enzymes (as far as we know!), and the gut mucins are a bit different from those found on the endothelium, largely because they have different functions. The gut (and …

Yes, something along these lines, and maybe the other pathways as the most interesting possibility. I don’t know if there any reports of sTn in older mice, but that would be pretty…

Catflap is a surprisingly apt analogy. In this case it is an endocytosis receptor, that selects cargo for uptake. Differs from virus to virus of course, but I could see changes in …

Fun fact: The AAVR (AAV receptor) is itself a glycoprotein (carrying the precise type of glycosylation they are trying to repair with the “gene therapy”). Haven’t read up what repl…

We don’t know is the answer. However, if you were coral, then I would suggest increasing the amount of symbiotic algae, which stimulates mucin secretion (probably a nutrient boost)…

This area is very much in my wheelhouse (both the biosynthetic process, and functions of mucins). They’re a pretty interesting biomolecule, present in all animals (slightly differe…