Viewing profile — gpcr1949

I think it is an underestimation to say ~800 people died in the Gaza war. The Ukraine number also seems like a serious underestimation.

Israel is committing what some experts are calling a genocide. In any case, they killed a lot of civilians. It can probably be debated whether this is noble or "striving to be bett…

I am really surprised they fired him for a really relatively mild series of tweets. I know some of the Israeli scientists leading the campaign against him also pointed out he tweet…

Writing Basel as Bâle would be silly and non-standard too, yes. Maybe "wrong" is too strong of a classification. But for example, I wouldn't immediately recognize it as Basel in a …

Interesting history, but people in Leuven call this city Leuven and not Louvain. No need to use the french term in a flemish city where almost no one speaks french as their first l…

https://archive.vn/lByGj

They use a random forest classifier, which is an ensemble model that gives a consensus result of several decision trees. One way to achieve this consensus is voting. Random forest …

High-throughput screening (HTS), i.e. testing a large amount of compounds in simple biochemical assays can't be compared with testing 10 compounds in monkeys. The point of HTS is f…

You can read about the development of this new route and its advantages here [0]. Ctrl+F for ibuprofen or go to p.54. https://sci-hub.se/10.1016/B978-0-12-804190-1.00004-5

Agreed the process is very simple. The innovation that makes the resolution worth it is (as Derek also mentioned in the blog post) an efficient way to re-racemize the L-meth to DL-…

This is really a scandalously misinformed stunt. The chemical they released is SO_2 - one of the gasses and car pollutants causing acid rain.

I was wondering the same thing. I found this in a guardian article > The military’s firefighters use aqueous film-forming foam, or AFFF, which contains extremely high levels of PFA…

Good to see the results respect Benford's law and are therefore not fabricated.

I may be misreading it, but doesn't the GoL as commonly understood also depend on diagonal neighbors (i.e. 8 direct neighbors)? In that case the rule space would explode beyond the…

BOL-148 is not like the others. All others are N1-acyl analogs of LSD, so unlike bol148 they rapidly metabolize to LSD proper. This also means until they make a prodrug or analog l…

They definitely will, this is after all the intended purpose of these firms, and some of the more professional among them are producing cGMP APIs at scale in a completely legitimat…

Fluorine on an aromatic ring is not labile: other examples of substances with fluorinated aromatic rings are fluoxetine(prozac), citalopram (celexa) and paroxetine (paxil), which a…

With all due respect for the forensic chemists and their good work on identifying an unknown substance, it is fairly common for forensic groups to once in a while detect new chemic…

Pretty unlikely. The F would be already in place at an early stage, the precursor is probably 2-F-benzonitrile, alternatively 2-f-phenylmagnesium bromide.

(I have a background in organic chemistry as well) I somewhat disagree with this. Measuring chemical similarity is notoriously difficult, see these two interesting blog posts from …