Viewing profile — fragcula

> I think we're just disagreeing on different interpretations of the word effective. That's likely. I'm using the word in the sense of clinical efficacy, i.e. how likely an interve…

Oh I see. No ECT is most certainly the most efficacious treatment for depression we have. Talking therapies have a respone rate in depression of circa 40% [0], probably just slight…

abelacimab in particular was quite worrying. The BMJ (the journal OP posted) contained a criticism of that. Similarly as you say is that because numbers are easy to think about ant…

I'm not sure what part of what I said you disagree with. Nothing in the NICE guidelines explains how ECT works - because like the rest of the world NICE does not know. Once odd asp…

We also don't know who CBT works for what it's worth. It's also fairly limited in suitability (good luck with someone with catatonic depression trying to get them do a hot cross bu…

An extra foible is that many medications have psychiatric side effects. So even if you're prescribed a statin for the biochemical effect on cholesterol you might get some of the pu…

The interesting bits, for me, are the imaging scans which are expensive and slow and you need more than one for comparison per subject. Secondly the 'covert treatment' aspect, and …

It's interesting that anyone other than the R&D arm of the pharma industry even cares how it works. From the medical side what's important is what risk/benefit which is independent…

It's a shame that the imagining is so expensive, because I'd love to see a true control arm with placebos and follow up scans. i.e. if you are on a placebo and are told you will ge…

The psychiatrists themselves don't need to do both, as doctors practicing EBM they are interested in proven results. The decision to recommend a treatment (and to accept it) is bas…

> Other clinicians say, however, that the notion of depression being because of a simple chemical imbalance is outmoded anyway, and that antidepressants remain a useful option for …