Viewing profile — drug_design_PhC

> It's possible that it's very difficult to engineer a virus that can do better than anything nature has come up with As someone finishing a PhD in computer-aided drug discovery, t…

> Coevolution was part of it, but the actual "breakthrough" in their paper was the use metagenome sequences for protein structure prediction Ah -- I hadn't read into the metagenomi…

I was surprised to see the "breakthrough" in this article. The idea to use correlated mutations to identify contacting residues has been around since the 90's [1](if not earlier), …