Viewing profile — dmckinno

OpenAI beat me to the punch in publishing on this, but my results are similar. I hope that these convince you :-) https://openai.com/index/diagnose-rare-childhood-diseases/

Sharing this both because it is phenomenal work that will bring peace to 18 families and addresses some of the questions raised when I posted my Gamow Labs founding story last week…

This was short read. I'm in the process of getting my first batch of long reads, but I am skeptical that this is the "just" what's needed. There is little doubt that long read > sh…

Current genomic techniques involve humans using a lot of different software (search, ranking models, visualizations, alignment algorithms, etc.) and synthesizing the results manual…

Thanks for sharing (I am OP). Lots of really interesting computational problems in genetics. The original speech recognition models, HMMs, diffused to genetics ahead of many other …

> Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense.…

Opus-4.8/GPT-5.5 coupled with their respective harnesses will do a good job for more vanilla cases, I realized a custom harness and set of skills and MCP servers became essential a…

This was not intended to be a technical post (obvious I hope). I'm planning on getting one out in the next few weeks characterizing the system and how it performed on real clinical…

It's funny you mention Dr. Kingsmore and Rady. While I am truly grateful for him and the team for their contributions to neonatal genetics (and hosting me in San Diego for a few da…

This is kind of like the reverse of the sister comment, which I agree with: https://news.ycombinator.com/item?id=47242699 The general point is that separating PM and eng doesn't ma…

I don't remember the exact name, but the one about AI productivity. It should be trivial to find my name from my handle, so just look at my profile.

100%. PMs at startups already wear many hats and AI helps them do that even better. But to this sister comment's point, I do think that the dedicated PM role will vanish and the cl…

I totally agree (as a PM of ~10 years). I think that all PMs will need to get onto the engineering, design, or research ladder. We are already seeing companies eliminate the functi…

Communicating a feature with a doc or mock can be really hard. A prototype can make things much clearer to a broad audience.

Thanks! I posted that one almost a year ago and it blew up on LinkedIn of all places but was totally ignored on HN.

You'd be surprised. See this sister comment: https://news.ycombinator.com/item?id=47242372

Weird take. Coding is fun (and has been since before AI). And vibe coding is fun in an entirely different way.

Funny story: I work at Meta and posted a version of this internally in response the bizarre pressure and support for PMs landing prod diffs (the response was very positive FWIW).