Viewing profile — david_l_lin

I should clarify: there’s some more details to why S mutans actually requires low pH. The correct term wouldn’t be “tolerate low pH” but rather “requires low pH” for its stable col…

This story has been around for far too long and evidence is unbelievably weak, and the claims border on fraudulent. 1. The claim that this strain outcompetes the same S mutans from…

Indeed we do! We have an oral microbiome test you can find here: https://www.bristlehealth.com/pages/products and our first probiotic here: https://www.bristlehealth.com/pages/prob…

Except that we can! The oral microbiome can be modulated to get exactly what you’re asking: remove pathogens that are good at creating acid and replacing them with ones that are go…

Majority were not on medication. >Eighty-five FES patients and 35 CHR subjects were psychotropic medication naïve and all participants were free of substance abuse, suicidal ideati…

Super interesting study! Other studies also associated the oral microbiome with cognitive health, like depression and Alzheimer's, but this is an interesting finding. >H2S-producin…

In the last 5 years or so, research has shown tight associations between specific pathogens in the mouth and inflammation throughout the body. Fusobacterium nucleatum and colorecta…

well, for the most part in healthcare we treat symptoms not causes. cavities caused by acid producing bacteria? drill and fill gum disease caused by oral dysbiosis? bone and gum gr…

It's interesting that we've become so obsessed with the gut microbiome even though stool only captures a tiny fraction of the composition of the gut. Similarly, the salivary oral m…

All you need to do is visit the dentistry reddit sub and look at threads like this: https://www.reddit.com/r/Dentistry/comments/vnv25a/how_is_he... . They all operate on "productio…

I think it's because incumbents in the space have played a huge role in preventing adoption of new technologies that actually prevent disease. Dentists make money not from preventi…

I wonder if the same is happening to mouth microbes, which could explain the epidemic of oral disease in developed countries.

Fee for service in health care is not compatible with prevention. The vast majority of oral issues are preventable because they stem from bacterial infections. Dentists take full a…

Honestly, neither. Biology is complex and messy, and often not at all intuitive.

Just watched John Q (2002) last night, and can't believe that despite all the attention it gets, nothing has changed at all. Can't say I'm surprised though.

A lot of studies have shown that literally taking up genomic space is a function. So by definition, all genes have a function. Non-genes have functions. The topological organizatio…

Even an exogenously expressed non-human protein still has a "function". even if you force it to be expressed. We may not understand its effects, but it is certainly doing something…

> "this outcome fails when this byte of data is missing" The outcomes here are not failures, they are measurable phenotypic differences, which they use to group genes into phenotyp…

All genes have a function. This paper helps us understand genes of unknown function (which is a LOT of them). Some of these functions are not intuitive: maybe they regulate the fun…

Not really? It says that some genes result in the same outcome when knocked out as other genes, and identifies novel genes that putatively participate in the same pathways as other…

Bristle cofounder here. In short, we found that people using an electric toothbrush have increased commensal species in their oral microbiome compared to those using a manual brush…

>you will get paid SIGNIFICANTLY less than you would doing almost anything else Definitely true. >have zero autonomy Might be true? But in the right research group, this is definit…

Healthcare is notoriously slow with adoption of new technology. IMO this is because healthcare is fee-for-service, which is basically incompatible with prevention. A movement to va…