Viewing profile — csaid81

Yes, but not only did they improve the memory of mouse models of Alzheimer's, they also improved the memory of older wild-type mice, which seems impressive to me. https://www.natur…

I know a lot of legitimate research supports various versions of the amyloid hypothesis, but I don't buy that these likely fraudsters had minimal impact. You said that Lesné was "n…

Sorry, here's the correct link https://chris-said.io/2024/06/17/the-case-for-criminalizing-...

He could be prosecuted under current fraud laws, but this hardly ever happens. I wrote a blog post on how to make this easier, including a new criminal statute specifically tailore…

Blog post author here. The paper was the 4th most cited paper in Alzheimer's research since 2006. So I feel reasonably confident that if it had never been written, some researchers…

I think the answer is not "nope" but "probably nope". That video is perhaps overconfident in our ability to detect these storms. From the article: > One-third of major storms arriv…

Thanks for the link! Good stuff. By the way, dplyr doesn't use multi-indexes. I actually think this one of the reasons (although not the biggest reason) dplyr is easier to use.

Pandas makes lots of backwards-incompatible changes. See for example these changes in the latest release http://pandas.pydata.org/pandas-docs/version/0.18.0/whatsnew... There have …

Here's some specific examples: https://twitter.com/Chris_Said/status/715249097326768128 https://twitter.com/Chris_Said/status/861244045535756290 I could be wrong, but I'm pretty su…

Right, but I'm talking about the pandas API. Stuff like how easy it is to remember exactly how to do aggregations, transformations, etc.

It's great that the Moore Foundation provided funding for open source data science tools in Python. Good for them! That being said, I do wonder if numpy is the most appropriate rec…

Yup, I agree about throwing away rater information. The actual application at my company that motivated me to research this doesn't have rater information, which is why I didn't th…

Got it. Thanks for the clarification. In that case I would think that James-Stein / Buhlmann / BLUP is a better approach, since it is just as easy to implement and the amount of sh…

This seems different and a bit lacking in detail (although I don't dispute that it could be useful). How exactly does one choose m and C? And what are the conditions under which it…

Author here. Please see the section on mixed models in my post. As I mentioned there, I would love if an expert could expand on the relationship between mixed effects and Empirical…

It's an excellent blog post, although it's worth emphasizing that it is designed for the binomial case, where you wish to compute the fraction of occurrences within some events, su…