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I believe this is to improve performance by shortening the context window for long thinking processes. I don't think this is referring to real-time summarizing for the users' sake.…

LLMs are in many ways text predictors. Could you have an LLM that runs in realtime, watching a speech on TV for example, and predicts what the person is going to say 5 seconds in a…

For example, in the recent Phase 2b CB1 agonist for cannabis user disorder from AELIS, the FDA required a standard of efficacy of an 80% reduction in use. The trial failed for unre…

I’ve lost 60 pounds and my health has improved considerably. I was overeating out of boredom and stress. I’ve been able to reduce my blood pressure medication. My blood sugar is mu…

yes

A new, large retrospective study of patient health records shows a 40% drop in opioid overdoses and a 50% drop in cases of alcohol intoxication among people who received GLP-1RAs (…

And if you haven't asked a friend who's on one, taking a GLP-1 medication reduces drinking by about 50%: https://recursiveadaptation.com/p/first-ever-randomized-tria...

"These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger…

“I’m now offering GLP-1s to nearly all my substance use disorder patients.”

This shape, known since at least Plato's time and named by Kepler, has fascinated thinkers from Archimedes to Buckminster Fuller. As its name implies, it's somewhere between a cube…

"Because the pharma companies with approved GLP-1s do not pursue addiction treatment, a large scale trial and FDA indication will not happen on its own. Without a strategic public …

If you're interested in the addiction side of this, I write the substack that Scott links to in this post. Here's the article he links to: https://recursiveadaptation.com/p/the-gro…

GLP-1 Rapid Access Care (GRACE) is a proposed model of opioid harm reduction that would provide immediate access to GLP-1RA craving reduction treatment for people with OUD without …

Smoking causes more deaths than any other substance use disorder. In the US, 480,000 people die annually from smoking-related causes. A new real-world retrospective cohort study us…