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Viewing profile — cknoxrun

cknoxrun

HN member
Joined
Thu, Oct 02, 2014, 4:55 PM UTC
HN karma
510
Public activity
146 items

About cknoxrun

CTO at DrugBank (www.drugbank.com), the worlds largest database on Drugs and Drug Targets.

Recent public activity

  1. comment
    Comment #48390527

    Google is actively, and directly helping companies continuously train use-case specific models based on Gemma 4 foundation. The company gets a model they fully own, trained on inte…

  2. comment
    Comment #48247634

    The interesting part is that agents are good at adding the safety layers (type safety) that exist for Ruby, but which add developer/cognitive overhead (such as Sorbet). I actually …

  3. comment
    Comment #48063502

    I'm not sure where the original poster is from, but where I'm at (Canada) my local library has a large gaming collection, including Switch 2 games. The bigger games you have to wai…

  4. comment
    Comment #47471632

    Thanks for the clarification, I see where you are coming from and definitely agree it's a real problem. I'm proud to say for myself that devices never leave the home now (and mine …

  5. comment
    Comment #47459175

    The only thing I'll add is that you never know what people are going through. Both of my children have pretty intense ADHD, and when I went through my divorce I definitely leaned i…

  6. comment
    Comment #46531278

    Coming from another stressed out startup CTO, I'm curious what your daily meditation routine look like now?

  7. comment
    Comment #41593832

    I do like the approach Basecamp took to Kanban ("Card Table") - very very simple and clean ( https://basecamp.com/features/card-table ). We moved off of Basecamp but we found it su…

  8. comment
    Comment #32717849

    Only things he has asked for, this is not driven by a need for academic improvement or anything, but a chance to learn tools to improve a known deficit with ADHD that can negativel…

  9. comment
    Comment #32690493

    Interesting. I've often considered an Apple Watch for my 9 year old, who struggles with (and benefits from) ADHD and thus would benefit from specific features such as the reminders…

  10. comment
    Comment #29646184

    Not the greatest UI, but you can show 2 conversations at the same time by command-clicking on a person/channel (or right clicking on a second person/channel and choose "Open in spl…

  11. comment
    Comment #29559054

    Your question caused a likely ludicrous and unoriginal idea to pop into my head - I wonder if it would be possible to purposefully engineer and release a mutated form of a virus li…

  12. comment
    Comment #28679267

    A couple of friends of mine are the co-founders of one of the big gif sharing sites. I've heard some pretty interesting, and very funny, stories about the sticker shock on S3 as th…

  13. comment
    Comment #28407146

    Personally, this post made me aware there are existing alternatives to Codespaces. Codespaces is very cool, but it also adds to an ever-growing single point of failure, which is de…

  14. comment
    Comment #28185215

    There's an interesting book that discusses this, "To Sell is Human" by Daniel Pink that I think is worth a read.

  15. comment
    Comment #27927452

    We migrated a high-traffic, complex site with a huge amount of data to MariaDB about 5 years ago as well, and it's been solid so far. We use Galera as well, which has performed and…

  16. comment
    Comment #27774831

    I used Fellow briefly, but it was so incredibly slow. Glad to hear you are putting a big focus on performance! Submitted myself to the beta.

  17. comment
    Comment #27715822

    To preface this, I would love to see oil sands production halted. However, evidence seems to suggest it is far too idealistic to imagine a world where the oil manufacturers / count…

  18. story
  19. comment
    Comment #27547404

    PathWhiz is pretty general ( https://smpdb.ca/pathwhiz ) and covers most of that. Give it a go! You can sign in as a guest and start creating pathways. All of the gene information …

  20. comment
    Comment #27311304

    Even outside of SPA apps and new magic, Rails is still faster to develop a prototype or website in than React or dare I say any modern SPA tools. We tested this for fun with some v…

  21. comment
    Comment #27171160

    Interesting, I pointed it at my son and it immediately accurately described "a child sitting at a white table doing a jigsaw puzzle". I pointed at one of his Lego creations, and im…

  22. comment
    Comment #27028846

    There is a common fear (and I have to admit I irrationally feel this fear) that your ranking will be impacted negatively by not using Google Analytics. Maybe not intentionally, but…

  23. comment
    Comment #26891279

    Not sure when you used ActiveRecord, but slow query logging helps a lot to identify these issues. I also appreciate that in the docs for ActiveRecord they make it very clear that j…

  24. comment
    Comment #25394914

    It's actually a legitimate phenomenon: https://news.ycombinator.com/item?id=15643663

  25. comment
    Comment #25325297

    As a long time Rails developer, pushing products and prototypes out the door quicker than peers, it's heart-warming to see messages like yours more often on Hacker News lately.