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Forgive my ignorance - is that true even for non-synonymous mutations? They usually have a hard time disrupting the big structure?

If the mutations were non-synonymous, resulting in different amino acids, the fact that they keep the natural function is still kinda cool. Very much a pure research result AFAICT,…

Yes, I see. There's a desire to map intervals pointwise through functions, but also a desire to produce intervals by all-pairs calculations, and the impossibility of representing b…

> Why x^2 isn't always x * x It turns out he's claiming they're different if x^2 is interpreted as squaring each element in the interval x, while x * x is interpreted as a cross pr…

Not your mistake, he does his best to imply that the hats are dropping on heads. He's got a future in marketing.

But is that "willingness to do for a low price" some kind of inherent property of artists as a group of people, or does it come from somewhere else? (The "or" here is not necessari…

In the past I have thought about it as you do. But it occurs to me now that this is also a property of tech products, isn't it? These products can be built by a small team and serv…

This is the real story. Mouse Jiggles a Key Performance Indicator at Major US Bank.

While the law allows it, in my opinion there is no real moral basis for a company to lay claim to all of an employee's time. If the employee is sufficiently responsive and producti…

Providing objective, accurate, relevant contextual information that reasonably makes people outraged is not in itself an appeal to emotion and outrage. The information is relevant …

Why not go even further? Why not say that the whistleblower was wrong and Microsoft business leadership was right? Maybe their profits from ignoring this issue have been fantastic,…

I think that context about the company in the article is context about the article, but I understand your difference of opinion. To see my point, consider this pull quote from Well…

Context: in the 2010s, Wells Fargo management looked the other way while its sales force scammed customers, creating millions of fraudulent accounts (with associated fees) to meet …

Many of you will be familiar with this story: military pilot gear was once designed for the average person, but then they realized that actually, most people deviate significantly …

Leetcode-style tech interviews fall far short of standardized tests. In real standardized tests, the same questions are given to everyone, and effort is made to develop new questio…

> the fact that there is a standardized test ...a standardized test? No. There are tests. They sure as heck aren't standardized. Maybe they should be, since everyone seems to be do…

Hopefully it'll all be available in a fire sale when these companies finally have to be stripped for parts.

Believe it or not, we talk, and their input influences my actions.

The lack of communication of potentially valid reasons such as these might contribute to why people view RTO mandates with cynicism. If we knew why we were being asked to RTO, we c…

Apologies, my bad, but I'm a bit too late to edit. The experts say that R qualifies as a lazy language [1, 2]. My impression was that R was mostly an eager language that somehow al…

R is not lazy. It has non-standard evaluation mechanisms (formulas, promises, quosures...) that enable to you to write domain-specific languages that "do what the user meant". If y…

I think there is a law of convenience, and it also explains why many technologies improve at a consistent exponential rate. People are very good at finding convenient ways to make …

Abstract - admirably concise and accessible: > How will the emergence of ChatGPT and other forms of artificial intelligence (AI) affect the skill premium? To address this question,…

Weren't non-competes just banned by the FTC? Could make a fine mess of this.

And I suppose the individual owners were paying rent in some form to Red Lobster Inc, since it owned the land? It might be that all that changes for them is who they write the chec…