Viewing profile — chenja

Great idea. I used to always just count down so we could start Netflix at the same point, and then sync up after a bit by pausing and restarting occasionally, this is a very elegan…

very useful article! two other options I used before are just installing base R on EC2, or using this RStudio AMI I found from a Google search: http://www.louisaslett.com/RStudio_A…

We are definitely not experts in regards to pharma (neither Alice or I have experience working in pharma) but our advisors include pharma consultants and senior scientists. We're c…

Our video definitely was geared toward a lay audience, but we tried not to use buzzwords and bullshit and to explain the science in a more accessible way. I'm curious to know what …

We definitely didn't invent systems biology for drug discovery. But Google didn't invent search engines either, I think that we have a fresh and novel approach which is really diff…

I am a big believer in the prion-like spread hypothesis which seems to be a common thread for neurodegenerative disease, and led a study (in press) that supports this idea in Alzhe…

The 1000X number should only be attached to "cheaper", and comes from in vivo and in vitro validation experiments we have done; our drug hit rate was almost 1000X higher than high-…

YC doesn't provide advice about this in a systematic way, but we have been trying to learn how to engage the lay public mostly from talking to other YC founders. It's hard to commu…

We have been actively validating targets, and in fact Alice's PhD work was centered on performing the in vitro and in vivo validation experiments for computational drug leads. We a…

I really appreciate your feedback and of course we have studied a lot of what worked (and mostly, didn't work) in systems biology over the past decade, but the field has shifted dr…

While cheaper sequencing hasn't really produced much in the way of new treatments (yet), I disagree that it hasn't been productive or that sequence data is of low accuracy. For exa…