Viewing profile — bonsai_spool

This bonus, per the thread, has to be accepted for a candidate to get a job offer and has unclear implications for when a worker may leave. In this case it is closest to a 'signing…

> Why do you think it is not relevant to the problem of teacher recruiting? First, the issue with teacher pay is that it is low. OP and you would instead say that the issue is that…

> Teacher recruiting wouldn't be so hard if pay weren't lockstep, as it is in so many places. Unions demand this, and it keeps some potentially-effective teachers out of the profes…

The point is that this bonus is effectively a condition of hiring that has strings attached

> You want to train kids from a young age not to spend a long time on the toilet, which reading encourages. It consistently leads to hemorrhoids. That's just a fact. Whoa, you can …

> Back when we lived without phones, we used to read instruction labels on all and any household cleaning products that were stored in the bathroom. Wow, I forgot that I used to do…

I hear your hypotheticals about testing. I think this comes up often, by way of example, when somebody has been in the hospital for a long time. Long stays aren't always medical, t…

And written by an LLM, to boot.

I hear the complaint, all I can say is that everyone I speak to about this wants to diagnose things correctly while not wasting anybody's time or energy on bad diagnostic workups. …

I think endometriosis is common enough that it would be caught earlier ("Oh, does your joint pain get worse right before you menstruate? Tell me more"), but your point is reasonabl…

This relates to the Midjourney effort; previous HN discussions: - Original: https://news.ycombinator.com/item?id=48579650 (see https://www.nature.com/articles/s41551-026-01660-4 ) …

Understood, I responded elsewhere that I read the Lowe article as talking about conceptual advances (ACE, HMG CoA), but I realize he's mixing both erstwhile untreated indications a…

Not being rude, and I definitely know about medicine. I explained in sibling that I understood the Lowe article to be about new research (as a researcher, I don't often think about…

I did ask for examples. These aren't really the sort of thing the article is talking about - they're just recombinations of existing medications. I admitted in another comment that…

> Why isnt it rational? You can spend that $1B to win a new category or that same money to maybe be non-inferior to Keytruda, but maybe fail. I think copycat design does happen, bu…

You are correct. I disagree with alternatives being better as a rule but these are clearly areas where there's a market (to wit, people don't like injecting themselves and prefer p…

I have seen these people, but we are speaking about drug companies making new drugs. I am not aware of an example of a new chemotherapeutic developed to reduce the side effects of …

This is very facile thinking - are there any examples of a-e in the real world (namely, a brand new drug program was spun up to exploit a-e) ? I think not, which is why I asked the…

Cost of manufacture is not a meaningful driver of pricing outside the biological How will your clinical trial of the ostensible full cure work if standard of care is curing people?…

That isn’t how a rational person would pursue this - it costs $1B to make a drug start to finish, and there’s no reason to believe your new mechanism will work. If you’re talking a…

This comment makes no sense. Why would anyone make a drug if the current prevalent treatment was as good as a functional cure? What do lorbrena and keytruda have to do with the rat…

Wow, you’re my twin! I’d watch these on XBMC/Xbox Media Center with some other video podcasts - it was a magical moment in tech