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I completely agree that there are many scientific libraries in python which scale up. I was addressing the article which showed a more advanced way to use python with the purpose o…

The content in the article is a bit dated. Jupyter + Numba + Dask is the direction scientific computing (in Python) is taking. Ipyparallel is not really scalable in my experience.

http://crispr.mit.edu/about Designing a good gRNA is quite straightforward if you compare it to any other bioinformatics tasks. Even designing a degenerate primer is more complex t…

Do you mean the effect of the actual gene knockout, crispr specificity or off-spot mutations?

Synthego custom crispr kit seems like a very useless service. Guide RNA design for knockout is extremely trivial. You just need a couple of 20bp+NGG sequence which is unique to the…