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biomcgary

HN member
Joined
Wed, Aug 29, 2012, 3:34 AM UTC
HN karma
2,554
Public activity
684 items

About biomcgary

Computational biologist. Modeling individual human health using multi-omic approaches and machine learning. Searching for islands of causality in seas of correlation. Cross-species translation of biological systems: Of mice and men (and zebrafish, worms and yeast).

Recent public activity

  1. comment
    Comment #48562906

    My teenage boys are hooked on Calvin & Hobbes.

  2. comment
    Comment #48544856

    In Lakatosian terms, the amyloid hypothesis is an example of a degenerating research program that has largely failed to predict new observations and is primarily driven by post hoc…

  3. comment
    Comment #48492013

    But, datacenter development in space does not deal with local NIMBYs, just centralized decision-makers that are easier to "influence".

  4. comment
    Comment #48362716

    Gives new meaning to "gut intuition", since the superparamagnetic macrophages are in the liver.

  5. comment
    Comment #48297028

    My CEO did a deep dive into AI prototyping and eventually ran into a wall with data architecture and deployment. Fortunately, he realized very quickly that having human designed co…

  6. comment
    Comment #47896632

    Your username is uncanny for this comment. Well played.

  7. comment
    Comment #47536254

    The fact that you aren't persuaded is the evidence of collapse. Previous generations of LLMs persuaded everyone of anything.

  8. comment
    Comment #47381506

    I'm a non-Conformist is the historic sense. In the past decades, American Christianity has devolved into a smorgasbord of personality cults and group therapy that effectively suppr…

  9. comment
    Comment #47264418

    Do you know if any of these multi-stage approaches can run on an 8gb M1 Air?

  10. comment
    Comment #46332477

    Computational biologist with a focus on predicting individual human health at a startup, but I have ended up managing software engineers. (Scientist explore and engineers make the …

  11. comment
    Comment #46319660

    This explains the Scotch-Irish settling in Appalachia. It felt like home, but without the overbearing Brits nearby.

  12. comment
    Comment #46238524

    The Readme for a UI library benefits enormously from screenshots, even terminal based UIs.

  13. comment
    Comment #45675348

    The mind-body link is too important to get the causality wrong and The Body Keeps Score is an ideology where the causality only goes one way. I have a cousin that had frequent, ove…

  14. comment
    Comment #45629661

    Billions of cell derived from Henrietta Lacks agree with you.

  15. comment
    Comment #45482816

    I think you are getting at the need for tiered layers of abstraction and constraint. Simultaneously considering all possible ways to solve a problem doesn't work for humans or the …

  16. comment
    Comment #45420070

    Available data makes causality hard to get right. This paper is trying to get around known constraints with observational data (e.g., some people stop drinking when they start havi…

  17. comment
    Comment #45400584

    I didn't see a public source repository for keet, just compiled releases. Why would you trust closed source for a privacy app?

  18. comment
    Comment #45400527

    How does this avoid carrier grade NAT if everyone is on a cellphone?

  19. comment
    Comment #44986876

    The language around emotion often obscures the underlying reality that needs to be addressed. Emotions are the physiological manifestations of expectations and desires. (Emotion is…

  20. comment
    Comment #44986605

    True, in traditional corporate structures. I'm interested in how accountability flows in cooperative structures like Mondragon. (Accountability still flows down through those at th…

  21. comment
  22. comment
    Comment #44916787

    I bought a TENS 7000, which is #1 in Amazon's "Muscle Stimulators & Accessories" category. Mine came with a 9V battery. The specific "tens ear clips" that I purchased are no longer…

  23. comment
    Comment #44916370

    I forgot to mention that the entire setup is about $60 on Amazon, so, for the HN audience, the biggest factor to trying it will be your time and/or intellectual aversion to non-mai…

  24. comment
    Comment #44916176

    I use a TENS unit with an almost identical setup to the paper (ear clip is the same, duration is the same, frequency is 30hz instead of 25hz). My use of vagus stimulation is for ma…

  25. comment
    Comment #44676843

    I think the best way to actively read is to write down your own thoughts as commentary.