Viewing profile — bede

I too would far rather bear a token cost than have my sessions rot silently beneath my feet. I usually have ~5 running CC sessions, some of which I may leave for a week or two of i…

Thanks for publicising. I recently decided not to renew my Backblaze in favour of 'self hosting' encrypted backups outside the US. But I was horrified to learn that my git repos ma…

> Probably obvious for many, but I didn't realize ACs don't transport any air into the room, but just moves it around I had the same epiphany as you days after acquiring a CO2 moni…

> There’s another distance limit at work here, and that is the speed of light. It takes milliseconds for the signal in your phone to reach the hotel above ground and be handed over…

For BAM this could be a good place to start: https://www.htslib.org/benchmarks/CRAM.html Happy to discuss further

Author of [0] here. Congratulations and well done for resisting. Eager to try it! Edit: Have you any specific advice for training a fasta compressor beyond that given in e.g. "Usin…

A Zstd maintainer clarified this: https://news.ycombinator.com/item?id=45251544 > Ultimately, Zstd is a byte-oriented compressor that doesn't understand the semantics of the data i…

Fascinating, thank you.

Thanks for reminding me to benchmark this!

Yes, when doing anything intensive with lots of sequences it generally makes sense to liberate them from FASTA as early as possible and index them somehow. But as an interchange fo…

BAM format is widely used but assemblies still tend to be generated and exchanged in FASTA text. BAM is quite a big spec and I think it's fair to say that none of the simpler binar…

Thank you for clarifying this – yes the non-semantic nature of these particular line breaks is a key detail I omitted.

Exactly. The line breaks break the runs of otherwise identical bits in identical sequences. Unless two identical subsequences are exactly in phase with respect to their line breaks…

Yes I'd expect a dict-based approach to do better here. That's probably how it should be done. But --long is compelling for me because using it requires almost no effort, it's stil…

Yes, it sounds like 7-Zip/LZMA can do this using custom filters, among other more exotic (and slow) statistical compression approaches.

Just watched my iPhone 15 battery drop 2% scrolling for <60s

Thank you, perhaps the parent can be edited to use this URL instead

I assumed that the article must be about a frustrated CDC employee just trying to get internet access at work.

I also lost faith in certain scientists (and many more politicians) during the pandemic. But be wary of generalising about a such a large and interdisciplinary group of people. Voi…

Thanks for the recommendation

Thanks!

Not absolute, but pausing a sub with an explanation sends an immediate message. Which services would you recommend? I'm mostly after a broad and fresh electronic music catalogue.

Depth and breadth of electronic music catalogue and switching cost. Former is probably narrowing rapidly. What would you recommend? Building Apple's future streaming monopoly isn't…

As a scientist working in public health, this decision burned my faith in Spotify. They were taking down conspiracy theory podcasts daily while bankrolling Rogan to provide a platf…