Viewing profile — avogt27

Pedantic semantics gripe: DNA damage refers to actual damage to the DNA molecule (breakage of the sugar-phosphage backbone, loss of nucleosides, etc). DNA accumulates MUTATIONS ove…

Several crystal structures of the catalytic domain of the protein had already been determined. The DNA binding domain of the protein which AlphaFold predicted is a relatively commo…

I agree that this is probably at least partially a motivation, but it seems like a losing strategy to me. AlphaFold is run by a private company, and falsely elevating the importanc…

I think my problem is that this is maybe the most minimal and mundane use of AlphaFold, but it is treated like one of the main points of the paper. The small molecules they tested …

It's really a bummer to see this marketed as 'AI Discovers Something New'. The authors in the actual paper carried out an enormous amount of work, the vast majority of which is rel…