Viewing profile — aroch

> However–and here’s the rub–some 25 years after the human genome was sequenced, and despite huge efforts to link genes and disease, there are almost no SNPs that tell you anything…

I’m a fan of Saramonic’s MV2000 ( https://saramonicusa.com/sr-mv2000-large-diaphragm-usb-studi... ) is an affordable, good quality cardiod mic. Frequently available for $50 and sup…

I have ‘ccat’ aliases to the original cat binary

Nebula most likely ship your samples to China for processing and sequencing because it's so much cheaper. While that might not be a deal breaker for some, I would personally prefer…

Eh, your results look perfectly fine, especially for a budget sequencing run. Keep in mind there are a lot of repetitive DNA sequences that don't map well (search "mappability trac…

No one should be BLASTing individual reads... And pretty much no one is going to be assembling with OLC, even for ONT data. On the products page it says they provide FASTQs, aligne…

Not for home gamers, no. ONT is fairly low throughput and the prep is surprisingly difficult to do well without experience. You would need to run tens of flow cells to get enough s…

I have no skin in this particular game (Though I work in the sequencing industry), but... I don't think anyone is fooled/trying to trick anyone when they say "whole genome sequenci…

Lifetime license does not mean lifetime support. I get that that might be annoying, but why or how could they warranty third party software, that they don't control or version them…

Yes, but if your child is school age -- schools which are now increasingly going to in person instruction -- and you are immunocompromised, what are you going to do? Same question …

Not necessarily, you could have an immuno-compromised parent/grandparent

The point of vaccinating kids is: 1. They still get sick, even if asymptomatic, and can bring it home to the house where older people live 2. I don't know if there are published ca…

The answer to "Why are they investigating?" is simple and, in fact, driven in part by the pharmaceutical industry itself. First: The rate of thrombosis in AZ recipients is the less…

If you have a new model, hold the ionizer button for 5 seconds and the indicator light will turn off.

Strongly suggest using Let's Plot from JetBrains instead. It's much closer to ggplot2 in api and results. https://github.com/JetBrains/lets-plot

The Telomere-to-Telomere consortium has made fantastic progress on this in the last year or two: https://genomeinformatics.github.io/CHM13v1/ Thanks to them we now have a nearly co…

Sample prep, particularly if you want truly long reads, is 100% the hardest part. Funnily, there are people out there who want to teach army/marine grunts on the front line to run …

This isn’t the case anymore. Pathogen surveillance labs use Nanopore for single-base resolution variant calls to determine antibiotic susceptibility and to “fingerprint” against kn…

I think you're stuck in the biotech == people mindset. On the bacterial side, it is fantastic for quickly sequcinging and closing genomes. Personally, I think the killer use case i…

Over the last few years there have been several (4-5) instances of British subs nearly striking surface ships in their home waters. Also running aground right outside their home po…

Calling the British navy a battle ready fleet would be rather a positive attitude. Their submarine and surface ship captains don't know how to navigate, running aground and into ot…

Ah, I think so!

Oh Haxies, I remember writing run-time patches (aka, cracks) to bypass licensing/registration for several pieces of software. There was a common framework, whose name no eludes me,…

Lead dev here. While you're not wrong that we might be under-estimating risk, I'll note that we do take into consideration seroprevalence in our calculations (so called, ascertainm…

Lead dev here... Huh, didn't think I'd ever see my work show up on HN. Sadly getting an .edu institution to fork over the money for better scaling is hard... Even when it gets them…