Viewing profile — apathy

You could use transmissible preleukemia (eg CHIP in allo transplants) as an example if you wished. Direct unassisted clonal transmission in humans seems likely but, as you noted, i…

HTLV, EBV, HPV you better believe we have! It’s just rare (thank goodness).

Indeed, this is why hydrogen sulfide is toxic in smallish doses

Independent. The 60th vote was an independent who endorsed John McCain in preference to Obama. How can one person manage to be so consistently incorrect?

Remind us who tanked the public option in the ACA? Hint: he was Al Gore’s running mate a decade prior. And he was never a republican.

China tends to buy light crude instead of light sweet crude, hence the oil and derived fuels have more sulfur than is typical for European or American vehicles, industry, etc. This…

Oh good grief you’re right. This is doubly sad because using an ensemble metric for per-author eigenfactor seems like it would be tractable. Carl Bergstrom is a smart guy so I supp…

Aka eigenfactor

As a machine learning / probabilistic programming friend put it, (journal) peer review is boosting with three weak learners. Better than nothing, but very far from ironclad. Only r…

Timeless wisdom.

At least for lineage switching malignancies (5yo female was MLLr), I’m not sure anything other than synthetic lethal attacks on the clonal driver will help. MLL rearrangements in y…

Not mentioned here: the same results can in many cases be had from BiTEs at lower cost and without having to ship leukapheresis samples to the US in liquid nitrogen Having seen bot…

I bought one of these to teach a one-shot class on experimental design and statistics. To say it served the purpose would be an understatement. We blew through the CLT and derivati…

woo

This paper is a PR gold mine but a methodological disaster, which is par for the course in "EWAS" (epigenome-wide association studies). At one point I had to remind a coauthor that…

Posts like yours are the reason I come here. Great stuff. And yes glycoPTMs are insane.

sci-hub.tw does

Dubious — cellular senescence (whether proliferation- or oncogene-induced) is the usual failsafe for avoiding proliferation of damaged cells. It relies heavily upon TP53, RB1, and …

Also worth noting: this is further evidence that cancer, like many other diseases, is in part an immune disease. When central tolerance is too lax, tumor cells can more easily surv…

This is accurate in every field I’ve worked in (synthetic organic chemistry, comp chem, statistics, genetics, clinical trials). The top glam journals have an additional layer of po…

I download the illustrations (duh?). That’s the value. I don’t actually care about the service per se. Once the illustrations are in the paper/talk, the value has been realized, fo…

The phrase you may be looking for is “vertical market” and it’s a phrase that makes MBA types salivate. An underserved and overcapitalized vertical market can support amazing profi…

This. I sent them some vector art that was already better than 99.9% of figures in quality review articles, and they made it better. Nobody I know that has signed up for this servi…

Because these teams have never used (eg) google slides to put together a presentation from 3 different continents I have, and I’ll never go back to PowerPoint. Not coincidentally, …

JFC it’s a literal adaptimmune ad. “At Megaconglomco Inc, we use our patented pan-galactic gargleblaster fragments...” Here I thought we were going to see something like Steve Form…